黄体酮和雌二醇可调节小鼠精子的过度活化和体外受精的成功率。

IF 1.9 4区生物学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Journal of Reproduction and Development Pub Date : 2024-04-04 Epub Date: 2024-02-10 DOI:10.1262/jrd.2023-080

Miyu Fujikura, Masakatsu Fujinoki

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引用次数: 0

摘要

孕酮（P）和17β-雌二醇（Eβ）是众所周知的调节精子获能的激素配对。在这里，我们研究了 P 和 Eβ 对小鼠精子过度活化的调节作用，并评估了体外受精（IVF）的成功率。尽管P增强了精子的过度活化，但Eβ剂量依赖性地抑制了P增强的过度活化。此外，P 增加了体外受精的成功率，而 Eβ 则以剂量依赖的方式抑制了 P 诱导的体外受精成功率的增加。因此，P 和 Eβ 可竞争性地调节小鼠的过度激活和体外受精的成功率。由于P和Eβ的浓度通常在发情周期中发生变化，因此推测精子会根据输卵管环境的变化而获能，并使卵母细胞受精。

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Progesterone and estradiol regulate sperm hyperactivation and in vitro fertilization success in mice.

Progesterone (P) and 17β-estradiol (Eβ) form the well-known hormone pair that regulates sperm capacitation. Here, we examined the regulatory effects of P and Eβ on sperm hyperactivation in mice and evaluated the in vitro fertilization (IVF) success. Although P enhanced hyperactivation, Eβ dose-dependently suppressed the P-enhanced hyperactivation. Moreover, P increased IVF success, whereas Eβ suppressed the P-induced increase in IVF success in a dose-dependent manner. Thus, P and Eβ competitively regulate hyperactivation and IVF success in mice. Since P and Eβ concentrations generally change during the estrous cycle, sperm are speculated to capacitate in response to the oviductal environment and fertilize the oocyte.

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来源期刊

Journal of Reproduction and Development 生物-奶制品与动物科学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

2 months

期刊介绍： Journal of Reproduction and Development (JRD) is the official journal of the Society for Reproduction and Development, published bimonthly, and welcomes original articles. JRD provides free full-text access of all the published articles on the web. The functions of the journal are managed by Editorial Board Members, such as the Editor-in-Chief, Co-Editor-inChief, Managing Editors and Editors. All manuscripts are peer-reviewed critically by two or more reviewers. Acceptance is based on scientific content and presentation of the materials. The Editors select reviewers and correspond with authors. Final decisions about acceptance or rejection of manuscripts are made by the Editor-in-Chief and Co-Editor-in-Chief.