黄体酮和雌二醇可调节小鼠精子的过度活化和体外受精的成功率。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-04 Epub Date: 2024-02-10 DOI:10.1262/jrd.2023-080

Miyu Fujikura, Masakatsu Fujinoki

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引用次数: 0

摘要

孕酮（P）和17β-雌二醇（Eβ）是众所周知的调节精子获能的激素配对。在这里，我们研究了 P 和 Eβ 对小鼠精子过度活化的调节作用，并评估了体外受精（IVF）的成功率。尽管P增强了精子的过度活化，但Eβ剂量依赖性地抑制了P增强的过度活化。此外，P 增加了体外受精的成功率，而 Eβ 则以剂量依赖的方式抑制了 P 诱导的体外受精成功率的增加。因此，P 和 Eβ 可竞争性地调节小鼠的过度激活和体外受精的成功率。由于P和Eβ的浓度通常在发情周期中发生变化，因此推测精子会根据输卵管环境的变化而获能，并使卵母细胞受精。

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Progesterone and estradiol regulate sperm hyperactivation and in vitro fertilization success in mice.

Progesterone (P) and 17β-estradiol (Eβ) form the well-known hormone pair that regulates sperm capacitation. Here, we examined the regulatory effects of P and Eβ on sperm hyperactivation in mice and evaluated the in vitro fertilization (IVF) success. Although P enhanced hyperactivation, Eβ dose-dependently suppressed the P-enhanced hyperactivation. Moreover, P increased IVF success, whereas Eβ suppressed the P-induced increase in IVF success in a dose-dependent manner. Thus, P and Eβ competitively regulate hyperactivation and IVF success in mice. Since P and Eβ concentrations generally change during the estrous cycle, sperm are speculated to capacitate in response to the oviductal environment and fertilize the oocyte.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.