血浆中的镁、钙、钙镁比水平以及与代谢综合征和心脏代谢风险因素的关系。

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biological Trace Element Research Pub Date : 2024-12-01 Epub Date: 2024-02-12 DOI:10.1007/s12011-024-04088-6
Melissa Nunes Moia, Severina Carla Vieira Cunha Lima, Francisca Leide da Silva Nunes, Salomão Israel Monteiro Lourenço Queiroz, Dirce Maria Lobo Marchioni, Lucia Fátima Campos Pedrosa, Fernando Barbosa, Clélia de Oliveira Lyra, Karine Cavalcanti Maurício Sena-Evangelista
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引用次数: 0

摘要

镁和钙是与代谢综合征(MetS)相关的心脏代谢风险因素有关的元素。然而,关于血浆中钙镁比值(Ca/Mg)的影响还存在知识空白。因此,我们旨在评估血浆中的镁和钙水平以及血浆中的钙镁比值与 MetS 成分及其他心脏代谢风险因素之间的关联。这项横断面研究有 112 名成年人和老年人参加,分为 MetS 组(60 人)和非 MetS 组(52 人)。我们评估了社会人口学、人体测量学和生化数据。通过电感耦合等离子体质谱技术(ICP-MS)测量了血浆中的镁和钙水平。MetS的发病率很高,但各组间血浆中的镁和钙水平以及钙镁比值无明显差异。镁与 MetS 成分或其他心脏代谢风险因素之间没有关联(所有 p > 0.05)。钙水平与总胆固醇(β = - 0.020; p = 0.000)和高密度脂蛋白胆固醇(HDL-c)(β = - 0.046; p = 0.005)相关。总胆固醇(β = - 0.025;p = 0.000)和低密度脂蛋白胆固醇(LDL-c)(β = 0.017;p = 0.020)是钙镁比值的预测因子。这些结果表明,血浆中的钙和钙/镁比值与 MetS 相关的心脏代谢风险因素有重要关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma Levels of Magnesium, Calcium, Calcium to Magnesium Ratio, and Associations with Metabolic Syndrome and Cardiometabolic Risk Factors.

Magnesium and calcium are elements that have been associated with cardiometabolic risk factors related to metabolic syndrome (MetS). However, there are gaps in the knowledge regarding the impact of the calcium to magnesium (Ca/Mg) ratio in plasma. Thus, we aim to evaluate the associations between magnesium and calcium levels in plasma, and the Ca/Mg ratio in plasma with MetS components and other cardiometabolic risk factors. This cross-sectional study was carried out with 112 adults and older people, distributed into groups with (n = 60) and without MetS (n = 52). We evaluated sociodemographic, anthropometric, and biochemical data. Magnesium and calcium levels in plasma were measured by inductively coupled plasma mass spectrometry technique (ICP-MS). There was a high frequency of MetS, with no significant differences in magnesium and calcium levels and Ca/Mg ratio in plasma observed between groups. There were no associations between magnesium and MetS components or other cardiometabolic risk factors (all p > 0.05). Calcium levels were associated with total cholesterol (β =  - 0.020; p = 0.000) and high-density lipoprotein cholesterol (HDL-c) (β =  - 0.046; p = 0.005). The total cholesterol (β =  - 0.025; p = 0.000) and low-density lipoprotein cholesterol (LDL-c) (β = 0.017; p = 0.020) were preditors of the Ca/Mg ratio. These results indicate important associations of calcium and the Ca/Mg ratio in plasma with cardiometabolic risk factors related to MetS.

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来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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