注射吸毒者坚持接受 HCV 直接作用抗病毒疗法的情况

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-12 DOI:10.1038/s41575-024-00905-4

Jordan Hindson

引用次数: 0

摘要

发表在《肝脏病学杂志》上的一项新研究（HERO）调查了丙型肝炎病毒（HCV）感染和注射毒品患者坚持直接作用抗病毒治疗与持续病毒学应答（SVR）之间的关系。在为期12周的治疗期间，电子泡罩包装评估了注射吸毒者（n = 623人开始直接作用抗病毒治疗）对sofosbuvir和velpatasvir的依从性。总体 SVR 率为 92.7%，依从性中位数为 75%。较高的依从性与 SVR 相关。中断治疗和过早停药与较低的 SVR 有关；尤其是在第一个月中断治疗或中断治疗时间≥2 周的患者，其 SVR 较低。研究人员还发现，即使依从性只有 50%，SVR 也能达到 90%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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HCV direct-acting antiviral therapy adherence in people who inject drugs

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.