革兰氏阴性内溶素：克服外膜障碍

IF 5.9 2区生物学 Q1 MICROBIOLOGY

Current opinion in microbiology Pub Date : 2024-02-12 DOI:10.1016/j.mib.2024.102433

Hazel M Sisson , Simon A Jackson , Robert D Fagerlund , Suzanne L Warring , Peter C Fineran

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引用次数: 0

摘要

我们控制革兰氏阴性细菌病原体生长的能力受到了抗菌药耐药性不断增加的挑战，因此需要新的方法。内溶酶体是一种源于噬菌体的酶，能降解肽聚糖，因此有可能成为抗菌剂。然而，革兰氏阴性细菌的外膜（OM）阻碍了外部应用的内溶酶进入肽聚糖。本综述重点介绍了在发现和鉴定可突破外膜的天然内溶酶素方面的最新进展，以及提高内溶酶素对革兰氏阴性病原体抗菌效力的化学和工程方法。

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Gram-negative endolysins: overcoming the outer membrane obstacle

Our ability to control the growth of Gram-negative bacterial pathogens is challenged by rising antimicrobial resistance and requires new approaches. Endolysins are phage-derived enzymes that degrade peptidoglycan and therefore offer potential as antimicrobial agents. However, the outer membrane (OM) of Gram-negative bacteria impedes the access of externally applied endolysins to peptidoglycan. This review highlights recent advances in the discovery and characterization of natural endolysins that can breach the OM, as well as chemical and engineering approaches that increase antimicrobial efficacy of endolysins against Gram-negative pathogens.

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来源期刊

Current opinion in microbiology 生物-微生物学

CiteScore

10.00

自引率

0.00%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Host-microbe interactions: bacteria Cell regulation Environmental microbiology Host-microbe interactions: fungi/parasites/viruses Antimicrobials Microbial systems biology Growth and development: eukaryotes/prokaryotes