测定生物和非生物样品中 60 种液晶单体的方法

IF 9 Q1 ENVIRONMENTAL SCIENCES
Yuan Liu , Wen-Long Li , Zhong-Min Li , Kurunthachalam Kannan
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引用次数: 0

摘要

液晶单体 (LCM) 是一种合成有机化学品,广泛用于制造数字电子设备的液晶显示器 (LCD)。随着人类与电脑和智能手机等数字电子产品的互动日益频繁,暴露于液晶单体已成为一个公共健康问题。然而,关于生物和非生物基质中出现的 LCM 的研究却很有限。我们开发了一种方法,利用气相色谱-质谱法(GC-MS)测定电子垃圾面板(即电脑显示器)、室内灰尘、粪便和尿液中的 60 种 LCM。固体基质(即灰尘和粪便)采用固液萃取 (SLE) 方法提取,而液体基质(即尿液)则采用固相萃取 (SPE) 方法提取。室内灰尘和粪便提取物通过硅胶填料重力柱净化。方法的检出限(LOD)和定量限(LOQ)分别为 0.05-13.0 纳克/毫升和 0.18-39.1 纳克/毫升。液晶面板、灰尘、粪便和尿液中浓度为 10 和 100 纳克/毫升的所有目标分析物的回收率范围为 71-130%,标准偏差为 0.01-33%。对类似的强化样品进行重复分析,得出的日内和日间差异(CV)分别为 0.32-12.6% 和 0.76-14.3%。根据强化基质计算得出的基质效应为-28.5%至28.5%。该方法被用于分析液晶面板、室内灰尘、狗粪便和尿液,结果发现在 60 个目标 LCM 中分别含有 22、42、46 和 18 个 LCM。液晶面板(∑LCM = 1780 ± 165 纳克/平方厘米(台式电脑显示器);166900 ± 80100 纳克/平方厘米(智能手机屏幕))、室内灰尘(∑LCM = 2030 ± 1260 纳克/克)、狗粪便(∑LCM = 1990 ± 2000 纳克/克干重)和尿液(∑LCM = 24.0 ± 14.6 纳克/毫升)中均检出了低氯单体。所开发的方法可用于分析各种环境和生物样品中的 LCMs。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A method for the determination of 60 liquid crystal monomers in biotic and abiotic samples

A method for the determination of 60 liquid crystal monomers in biotic and abiotic samples

Liquid crystal monomers (LCMs) are synthetic organic chemicals widely used in the manufacture of liquid crystal displays (LCDs) of digital electronic devices. As human interactions with digital electronics such as computers and smartphones intensify, exposure to LCMs is a public health concern. Nevertheless, there is limited research on the occurrence of LCMs in biological and non-biological matrices. We developed a method to determine 60 LCMs in electronic-waste panels (i.e., computer monitors), indoor dust, feces, and urine using gas chromatography–mass spectrometry (GC–MS). Solid matrices (i.e., dust and feces) were extracted using a solid-liquid extraction (SLE) procedure whereas liquid matrices (i.e., urine) were extracted using solid phase extraction (SPE). Indoor dust and feces extracts were purified by passage through silica gel packed gravity columns. The method limits of detection (LODs) and quantification (LOQs) were in the ranges of 0.05–13.0 and 0.18–39.1 ng/mL, respectively. Recoveries of all target analytes fortified at concentrations of 10 and 100 ng/mL on LCD panels, dust, feces, and urine were in the range of 71–130%, with standard deviations of 0.01–33%. Repeated analyses of similarly fortified samples yielded intra-day and inter-day variations (CV) of 0.32–12.6% and 0.76–14.3%, respectively. Matrix effects, calculated from fortified matrices, ranged from −28.5% to 28.5%. The method was applied in the analysis of LCD panels, indoor dust, dog feces and urine, which were found to contain 22, 42, 46, and 18 of the 60 targeted LCMs, respectively. LCMs were found in LCD panels (∑LCM = 1780 ± 165 ng/cm2 for desktop computer monitors; and 166,900 ± 80,100 ng/cm2 for smartphone screens), indoor dust (∑LCM = 2030 ± 1260 ng/g), dog feces (∑LCM = 1990 ± 2000 ng/g dw), and urine (∑LCM = 24.0 ± 14.6 ng/mL). The developed method can be applied in the analysis of LCMs in a wide range of environmental and biological samples.

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