纳米医学在自身免疫方面的新策略。

IF 15.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Ajay S. Thatte , Margaret M. Billingsley , Drew Weissman , Jilian R. Melamed , Michael J. Mitchell
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引用次数: 0

摘要

自身免疫性疾病已成为全球最普遍的慢性疾病之一,约有 5%-7% 的人受到影响。随着自身免疫性疾病发病率的稳步上升,潜在的治疗策略也越来越多。近年来,对这些自身免疫性病症的基础研究发现了一些细胞靶点,为治疗提供了新的机会。然而,在获取和特异性对抗失调、自我反应的细胞,同时避免系统性免疫抑制和其他脱靶效应方面,关键挑战依然存在。幸运的是,纳米药物的不断进步可能会提供应对这些挑战的策略,并为临床带来创新的自身免疫疗法。通过精确的工程设计和合理的设计,纳米药物可以拥有各种物理化学特性、表面修饰和载体,从而可以将强效疗法特异性地靶向病理细胞和器官类型。纳米药物的这些进步已在癌症疗法中得到证实,并具有推动自身免疫疗法应用的广泛潜力。在本综述中,我们将重点讨论如何利用纳米医学的力量治疗全身普遍存在的自身免疫性疾病。我们阐述了开发自身免疫疗法的三个关键领域--避免全身性免疫抑制、平衡与免疫系统的相互作用以及提升当前递送复杂载体的平台--并强调了基于纳米药物的策略如何克服这些障碍,开发出下一代临床相关的自身免疫疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Emerging strategies for nanomedicine in autoimmunity

Emerging strategies for nanomedicine in autoimmunity

Autoimmune disorders have risen to be among the most prevalent chronic diseases across the globe, affecting approximately 5–7% of the population. As autoimmune diseases steadily rise in prevalence, so do the number of potential therapeutic strategies to combat them. In recent years, fundamental research investigating autoimmune pathologies has led to the emergence of several cellular targets that provide new therapeutic opportunities. However, key challenges persist in terms of accessing and specifically combating the dysregulated, self-reactive cells while avoiding systemic immune suppression and other off-target effects. Fortunately, the continued advancement of nanomedicines may provide strategies to address these challenges and bring innovative autoimmunity therapies to the clinic. Through precise engineering and rational design, nanomedicines can possess a variety of physicochemical properties, surface modifications, and cargoes, allowing for specific targeting of therapeutics to pathological cell and organ types. These advances in nanomedicine have been demonstrated in cancer therapies and have the broad potential to advance applications in autoimmunity therapies as well. In this review, we focus on leveraging the power of nanomedicine for prevalent autoimmune disorders throughout the body. We expand on three key areas for the development of autoimmunity therapies – avoiding systemic immunosuppression, balancing interactions with the immune system, and elevating current platforms for delivering complex cargoes – and emphasize how nanomedicine-based strategies can overcome these barriers and enable the development of next-generation, clinically relevant autoimmunity therapies.

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来源期刊
CiteScore
28.10
自引率
5.00%
发文量
294
审稿时长
15.1 weeks
期刊介绍: The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.
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