植物源性细胞外囊泡在炎症性肠病中的治疗应用和潜在机制。

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2025-02-01 DOI:10.1016/j.jare.2024.01.035

Jinling Li , Ting Luo , Dou Wang , Yao Zhao , Yuanxiang Jin , Guiling Yang , Xin Zhang

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引用次数: 0

摘要

背景：植物源性细胞外囊泡(PDEVs)是一种以磷脂双分子层为基本骨架，由蛋白质和核酸等多种功能成分包裹的膜泡。越来越多的研究证实，PDEVs 是治疗炎症性肠病（IBD）的潜在药物，并能在一定程度上弥补现有疗法的局限性：本综述总结了从不同来源获得的 PDEVs 在缓解 IBD 方面的最新进展和潜在机制。此外，该综述还讨论了 PDEVs 的可能应用和挑战，为探索新型、实用的 IBD 治疗策略提供理论依据：在 IBD 中，PDEVs 的串联机制可能会调节肠道微环境的平衡，尤其是免疫反应、肠道屏障和肠道微生物群。此外，药物负载可增强 PDEVs 的治疗潜力，尤其是在改善组织靶向性和稳定性方面。未来，不仅基于 PDEVs 的免疫疗法可能成为 IBD 的有效治疗方法，肠道屏障和肠道微生物群也将成为治疗 IBD 的新方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease

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Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease

Background

Plant-derived extracellular vesicles (PDEVs) are membrane vesicles characterized by a phospholipid bilayer as the basic skeleton that is wrapped by various functional components of proteins and nucleic acids. An increasing number of studies have confirmed that PDEVs can be a potential treatment of inflammatory bowel disease (IBD) and can, to some extent, compensate for the limitations of existing therapies.

Aim of review

This review summarizes the recent advances and potential mechanisms underlying PDEVs obtained from different sources to alleviate IBD. In addition, the review discusses the possible applications and challenges of PDEVs, providing a theoretical basis for exploring novel and practical therapeutic strategies for IBD.

Key scientific concepts of review

In IBD, the crosstalk mechanism of PDEVs may regulate the intestinal microenvironment homeostasis, especially immune responses, the intestinal barrier, and the gut microbiota. In addition, drug loading enhances the therapeutic potential of PDEVs, particularly regarding improved tissue targeting and stability. In the future, not only immunotherapy based on PDEVs may be an effective treatment for IBD, but also the intestinal barrier and intestinal microbiota will be a new direction for the treatment of IBD.

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.