核机械传导对皮肤干细胞命运调控的影响

IF 6 2区 生物学 Q1 CELL BIOLOGY
Leah C. Biggs , Yekaterina A. Miroshnikova
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引用次数: 0

摘要

哺乳动物皮肤是一个高度动态和再生的器官,长期以来一直被认为是一种机械活性的复合组织,能够承受身体运动产生的日常压缩力和拉伸力。重要的是,细胞和组织尺度的机械信号是皮肤形态发生和平衡的关键调节因子。这些信号在细胞外围被感知,并通过质膜内的机械敏感蛋白传递到细胞骨架网络,最终进入细胞核,调节染色质组织和基因表达。这些节点在细胞和组织尺度上产生一致的机械响应中的作用正在逐渐显现。在此,我们重点研究对哺乳动物皮肤发育和平衡维持至关重要的细胞质和细胞核机械敏感结构。我们提出,皮肤的机械状态,尤其是其核区的机械状态,是一个关键的调变器,可微调对器官正常功能至关重要的发育和平衡过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nuclear mechanotransduction on skin stem cell fate regulation

Mammalian skin is a highly dynamic and regenerative organ that has long been recognized as a mechanically active composite of tissues withstanding daily compressive and tensile forces that arise from body movement. Importantly, cell- and tissue-scale mechanical signals are critical regulators of skin morphogenesis and homeostasis. These signals are sensed at the cellular periphery and transduced by mechanosensitive proteins within the plasma membrane to the cytoskeletal networks, and eventually into the nucleus to regulate chromatin organization and gene expression. The role of each of these nodes in producing a coherent mechanoresponse at both cell- and tissue-scales is emerging. Here we focus on the key cytoplasmic and nuclear mechanosensitive structures that are critical for the mammalian skin development and homeostatic maintenance. We propose that the mechanical state of the skin, in particular of its nuclear compartment, is a critical rheostat that fine-tunes developmental and homeostatic processes essential for the proper function of the organ.

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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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