Shuo Yang, Bas W. A. Bögels, Fei Wang, Can Xu, Hongjing Dou, Stephen Mann, Chunhai Fan, Tom F. A. de Greef
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引用次数: 0
摘要
DNA 计算和 DNA 数据存储是新兴领域,为信息技术和诊断带来了新的可能性。这些方法使用 DNA 分子作为计算基底或存储介质,具有纳米级的紧凑性,可在非常规介质(包括水溶液、油包水微乳液和自组装膜化隔室)中运行,其应用范围超越了传统的硅基计算系统。要构建可处理和存储分子信息的 DNA 功能计算机,就必须继续开发计算和数据存储策略,并缩小这些领域之间的差距。在本综述中,我们将以神经网络和分区 DNA 电路为重点,探讨如何在 DNA 计算中利用 DNA。我们还讨论了在 DNA 中存储数据的新兴方法,以及 DNA 编码数据的写入、读取、检索和合成后编辑等相关主题。最后,我们深入探讨了 DNA 计算如何与 DNA 数据存储相结合,并探讨了 DNA 在未来信息技术和健康分析应用中用于近内存计算的问题。
DNA as a universal chemical substrate for computing and data storage
DNA computing and DNA data storage are emerging fields that are unlocking new possibilities in information technology and diagnostics. These approaches use DNA molecules as a computing substrate or a storage medium, offering nanoscale compactness and operation in unconventional media (including aqueous solutions, water-in-oil microemulsions and self-assembled membranized compartments) for applications beyond traditional silicon-based computing systems. To build a functional DNA computer that can process and store molecular information necessitates the continued development of strategies for computing and data storage, as well as bridging the gap between these fields. In this Review, we explore how DNA can be leveraged in the context of DNA computing with a focus on neural networks and compartmentalized DNA circuits. We also discuss emerging approaches to the storage of data in DNA and associated topics such as the writing, reading, retrieval and post-synthesis editing of DNA-encoded data. Finally, we provide insights into how DNA computing can be integrated with DNA data storage and explore the use of DNA for near-memory computing for future information technology and health analysis applications. DNA has emerged as an attractive substrate for molecular information processing. This Review explores the application of DNA for computing and data storage, as well as the route to integrate these fields.
期刊介绍:
Nature Reviews Chemistry is an online-only journal that publishes Reviews, Perspectives, and Comments on various disciplines within chemistry. The Reviews aim to offer balanced and objective analyses of selected topics, providing clear descriptions of relevant scientific literature. The content is designed to be accessible to recent graduates in any chemistry-related discipline while also offering insights for principal investigators and industry-based research scientists. Additionally, Reviews should provide the authors' perspectives on future directions and opinions regarding the major challenges faced by researchers in the field.