肠道微生物群与高血压及高血压相关并发症之间的因果关系：双向双样本孟德尔随机分析

IF 2.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology Pub Date : 2025-05-01 DOI:10.1016/j.hjc.2024.02.002

Changhong Miao , Xinyi Xu , Shuoxuan Huang , Lingyi Kong , Zhiwei He , Yihan Wang , Kuang Chen , Lu Xiao

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引用次数: 0

摘要

背景：最近的研究强调了肠道微生物群与高血压之间的关系：最近的研究强调了肠道微生物群与高血压之间的联系，但这种关系的确切性质仍不清楚：本研究旨在利用双样本双向孟德尔随机化（MR）分析肠道微生物群与高血压及相关并发症之间的因果关系：获取全基因组关联研究（GWAS）荟萃分析的汇总数据，包括来自 24 个队列的肠道微生物群 GWAS 数据，以及最新的高血压相关疾病 GWAS 数据。我们采用各种 MR 方法，包括逆方差加权（IVW）、MR-Egger、加权中位数、简单模式和加权模式，研究了肠道微生物群与高血压相关疾病之间的关系。对结果的稳定性进行了敏感性分析，反向 MR 分析评估了反向因果关系的可能性：涉及 199 个微生物类群和 4 种表型的孟德尔随机分析确定了 46 个与高血压及其并发症有潜在因果关系的微生物类群。经过Bonferroni校正，Victivallis属与高血压有很强的因果关系（OR=1.08，95% CI=1.04-1.12，P=9.82e-5）。这表明，Victivallis 属丰度每增加一个单位，患高血压的风险就会增加 8%：总之，这项研究确定了肠道微生物群与高血压以及常见相关并发症之间的因果关系。研究结果揭示了未来通过肠道微生物群干预治疗高血压和并发症的潜在目标和证据，为治疗探索提供了一条新途径。

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The Causality between Gut Microbiota and Hypertension and Hypertension-related Complications: A Bidirectional Two-Sample Mendelian Randomization Analysis

Background

Recent studies have highlighted a connection between gut microbiota and hypertension, yet the precise nature of this relationship remains unclear.

Objective

This research aims to analyze the causal link between gut microbiota and hypertension, along with associated complications, utilizing two-sample bidirectional Mendelian randomization (MR).

Materials and Methods

Summary data from genome-wide association studies (GWAS) meta-analyses, including gut microbiota GWAS data from 24 cohorts, and the latest GWAS data for hypertension-related conditions were acquired. Employing various MR methods, including Inverse-variance weighted (IVW), MR-Egger, Weighted Median, Simple Mode, and Weighted Mode, we investigated the association between gut microbiota and hypertension-related conditions. Sensitivity analyses were conducted for result stability, and reverse MR analysis assessed the potential for reverse causality.

Results

The Mendelian randomization analysis involving 199 microbial taxa and four phenotypes identified 46 microbial taxa with potential causal links to hypertension and its complications. Following Bonferroni correction, genus.Victivallis showed a robust causal relationship with hypertension (OR = 1.08, 95% CI = 1.04-1.12, P = 9.82e-5). This suggests an 8% increased risk of hypertension with each unit rise in genus.Victivallis abundance.

Conclusion

In conclusion, this study establishes a causal connection between gut microbiota and hypertension, along with common associated complications. The findings unveil potential targets and evidence for future hypertension and complication treatment through gut microbiota interventions, offering a novel avenue for therapeutic exploration.

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来源期刊

Hellenic Journal of Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.90

自引率

7.30%

发文量

审稿时长

56 days

期刊介绍： The Hellenic Journal of Cardiology (International Edition, ISSN 1109-9666) is the official journal of the Hellenic Society of Cardiology and aims to publish high-quality articles on all aspects of cardiovascular medicine. A primary goal is to publish in each issue a number of original articles related to clinical and basic research. Many of these will be accompanied by invited editorial comments. Hot topics, such as molecular cardiology, and innovative cardiac imaging and electrophysiological mapping techniques, will appear frequently in the journal in the form of invited expert articles or special reports. The Editorial Committee also attaches great importance to subjects related to continuing medical education, the implementation of guidelines and cost effectiveness in cardiology.