急性心肌炎的当前治疗和免疫调节策略。

IF 2.6 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Pharmacology Pub Date : 2024-05-01 DOI:10.1097/FJC.0000000000001542

Emma Ferone, Amitai Segev, Erika Tempo, Piero Gentile, Ahmed Elsanhoury, Chiara Baggio, Jessica Artico, Prashan Bhatti, Paul Scott, Emanuele Bobbio, Marco Merlo, Pietro Ameri, Gianfranco Sinagra, Carsten Tschöpe, Daniel Bromage, Antonio Cannata

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引用次数: 0

摘要

心肌炎是一种心肌炎症性疾病，其表现和演变具有很大的异质性。心肌炎的治疗通常是支持性的，而免疫抑制的证据很少，且存在争议。传统治疗以临床表现为基础，从保守治疗到先进的机械辅助装置治疗。在这种情况下，免疫抑制和免疫调节疗法多用于出现主要临床综合征的患者。在这篇综述中，我们将总结针对急性心肌炎患者的常规治疗和免疫抑制治疗的现有证据和策略。

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Current Treatment and Immunomodulation Strategies in Acute Myocarditis.

Abstract: Myocarditis is an inflammatory disease of the myocardium characterized by a great heterogeneity of presentation and evolution. Treatment of myocarditis is often supportive, and the evidence for immunosuppression is scarce and debated. Conventional treatment is based on clinical presentation, ranging from conservative to advanced mechanical assist devices. In this setting, immunosuppression and immunomodulation therapies are mostly reserved for patients presenting with major clinical syndromes. In this review, we will summarize the current evidence and strategies for conventional and immunosuppressive treatments for patients presenting with acute myocarditis.

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来源期刊

Journal of Cardiovascular Pharmacology 医学-心血管系统

CiteScore

5.10

自引率

3.30%

发文量

367

审稿时长

1 months

期刊介绍： Journal of Cardiovascular Pharmacology is a peer reviewed, multidisciplinary journal that publishes original articles and pertinent review articles on basic and clinical aspects of cardiovascular pharmacology. The Journal encourages submission in all aspects of cardiovascular pharmacology/medicine including, but not limited to: stroke, kidney disease, lipid disorders, diabetes, systemic and pulmonary hypertension, cancer angiogenesis, neural and hormonal control of the circulation, sepsis, neurodegenerative diseases with a vascular component, cardiac and vascular remodeling, heart failure, angina, anticoagulants/antiplatelet agents, drugs/agents that affect vascular smooth muscle, and arrhythmias. Appropriate subjects include new drug development and evaluation, physiological and pharmacological bases of drug action, metabolism, drug interactions and side effects, application of drugs to gain novel insights into physiology or pathological conditions, clinical results with new and established agents, and novel methods. The focus is on pharmacology in its broadest applications, incorporating not only traditional approaches, but new approaches to the development of pharmacological agents and the prevention and treatment of cardiovascular diseases. Please note that JCVP does not publish work based on biological extracts of mixed and uncertain chemical composition or unknown concentration.