{"title":"尼日利亚西南部不育男性精子 DNA 碎片指数的模式和价值及其与精子图的相关性","authors":"B.O. Ibitoye , F.O. Bashir , F.O. Ibitoye , O. Alabi , O.T. Olaniyan , P. Faduola , O.D. Bamisi , A.J. Ajibare , S.D. Omoseeye","doi":"10.1016/j.morpho.2024.100763","DOIUrl":null,"url":null,"abstract":"<div><p>Semen analysis has been used for a long time to assess male fertility due to its limitations sperm DNA fragmentation index (DFI), which describes the sperm DNA's condition, is an appropriate criterion for assessing male fertility. This study evaluated the pattern and value of DFI of infertile men in the South West of Nigeria. This is a cross-sectional and descriptive study that recruited two hundred and eighty-seven (287) patients from two fertility centers in Lagos, Nigeria. The Sperm DFI was determined using the Sperm chromatin structure assay (SCSA) test. The descriptive and inferential statistics of the study were carried out using R packages (R version 4.2.0) with the help of R functions using compiled code. The result showed that the mean age sperm concentration, total motility morphology, and DFI were as follows 42.96<!--> <!-->±<!--> <!-->7.09<!--> <!-->years, 40.18<!--> <!-->±<!--> <!-->4.19<!--> <!-->×<!--> <!-->10<sup>6</sup> per ml, 49%<!--> <!-->±<!--> <!-->19%, 56<!--> <!-->±<!--> <!-->17%, and 15.78<!--> <!-->±<!--> <!-->8.52 respectively. There is a significant negative correlation between sperm concentration and DFI at a <em>P</em>-value of 0.0018 with a regression model of Coefficient of determination is 0.305. The DFI value of infertile men negatively correlates with sperm concentration, thus increase sperm production may improve sperm quality.</p></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pattern and value of Sperm DNA Fragmentation Index and its correlation with spermiogram in infertile South West Nigerian Men\",\"authors\":\"B.O. Ibitoye , F.O. Bashir , F.O. Ibitoye , O. Alabi , O.T. Olaniyan , P. Faduola , O.D. Bamisi , A.J. Ajibare , S.D. Omoseeye\",\"doi\":\"10.1016/j.morpho.2024.100763\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Semen analysis has been used for a long time to assess male fertility due to its limitations sperm DNA fragmentation index (DFI), which describes the sperm DNA's condition, is an appropriate criterion for assessing male fertility. This study evaluated the pattern and value of DFI of infertile men in the South West of Nigeria. This is a cross-sectional and descriptive study that recruited two hundred and eighty-seven (287) patients from two fertility centers in Lagos, Nigeria. The Sperm DFI was determined using the Sperm chromatin structure assay (SCSA) test. The descriptive and inferential statistics of the study were carried out using R packages (R version 4.2.0) with the help of R functions using compiled code. The result showed that the mean age sperm concentration, total motility morphology, and DFI were as follows 42.96<!--> <!-->±<!--> <!-->7.09<!--> <!-->years, 40.18<!--> <!-->±<!--> <!-->4.19<!--> <!-->×<!--> <!-->10<sup>6</sup> per ml, 49%<!--> <!-->±<!--> <!-->19%, 56<!--> <!-->±<!--> <!-->17%, and 15.78<!--> <!-->±<!--> <!-->8.52 respectively. There is a significant negative correlation between sperm concentration and DFI at a <em>P</em>-value of 0.0018 with a regression model of Coefficient of determination is 0.305. The DFI value of infertile men negatively correlates with sperm concentration, thus increase sperm production may improve sperm quality.</p></div>\",\"PeriodicalId\":39316,\"journal\":{\"name\":\"Morphologie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Morphologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S128601152400002X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Morphologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S128601152400002X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Pattern and value of Sperm DNA Fragmentation Index and its correlation with spermiogram in infertile South West Nigerian Men
Semen analysis has been used for a long time to assess male fertility due to its limitations sperm DNA fragmentation index (DFI), which describes the sperm DNA's condition, is an appropriate criterion for assessing male fertility. This study evaluated the pattern and value of DFI of infertile men in the South West of Nigeria. This is a cross-sectional and descriptive study that recruited two hundred and eighty-seven (287) patients from two fertility centers in Lagos, Nigeria. The Sperm DFI was determined using the Sperm chromatin structure assay (SCSA) test. The descriptive and inferential statistics of the study were carried out using R packages (R version 4.2.0) with the help of R functions using compiled code. The result showed that the mean age sperm concentration, total motility morphology, and DFI were as follows 42.96 ± 7.09 years, 40.18 ± 4.19 × 106 per ml, 49% ± 19%, 56 ± 17%, and 15.78 ± 8.52 respectively. There is a significant negative correlation between sperm concentration and DFI at a P-value of 0.0018 with a regression model of Coefficient of determination is 0.305. The DFI value of infertile men negatively correlates with sperm concentration, thus increase sperm production may improve sperm quality.
期刊介绍：
Morphologie est une revue universitaire avec une ouverture médicale qui sa adresse aux enseignants, aux étudiants, aux chercheurs et aux cliniciens en anatomie et en morphologie. Vous y trouverez les développements les plus actuels de votre spécialité, en France comme a international. Le objectif de Morphologie est d?offrir des lectures privilégiées sous forme de revues générales, d?articles originaux, de mises au point didactiques et de revues de la littérature, qui permettront notamment aux enseignants de optimiser leurs cours et aux spécialistes d?enrichir leurs connaissances.
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