内耳有机体：优势与局限。

IF 2.4 3区医学 Q3 NEUROSCIENCES

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2024-02-01 Epub Date: 2024-02-09 DOI:10.1007/s10162-024-00929-2

Giulia Pianigiani, Marta Roccio

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引用次数: 0

摘要

由人类多能干细胞分化而来的内耳器质性组织最近已成为研究内耳发育和发育缺陷的工具。这项技术的另一个令人兴奋的方面是它的转化潜力，特别是利用有机体验证人类/患者特异性细胞的听力和平衡恢复疗法。本文将简要讨论后一个方面，包括机遇和目前的局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Inner Ear Organoids: Strengths and Limitations.

Inner ear organoids derived from differentiation of human pluripotent stem cells have recently gained momentum as tools to study inner ear development and developmental defects. An additional exciting aspect about this technology is represented by its translational potential, specifically, the use of organoids to validate therapeutics for hearing and balance restoration on human/patient-specific cells. This latter aspect will be briefly discussed here including opportunities and current limitations.

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来源期刊

Jaro-Journal of the Association for Research in Otolaryngology 医学-耳鼻喉科学

CiteScore

4.10

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： JARO is a peer-reviewed journal that publishes research findings from disciplines related to otolaryngology and communications sciences, including hearing, balance, speech and voice. JARO welcomes submissions describing experimental research that investigates the mechanisms underlying problems of basic and/or clinical significance. Authors are encouraged to familiarize themselves with the kinds of papers carried by JARO by looking at past issues. Clinical case studies and pharmaceutical screens are not likely to be considered unless they reveal underlying mechanisms. Methods papers are not encouraged unless they include significant new findings as well. Reviews will be published at the discretion of the editorial board; consult the editor-in-chief before submitting.