评估益生菌治疗肠易激综合征的疗效。

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion Pub Date : 2024-01-01 DOI:10.1016/j.endien.2024.01.003

Cristina Ruiz-Sánchez, Blanca Escudero-López, María-Soledad Fernández-Pachón

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引用次数: 0

摘要

肠易激综合征（IBS）是一种以腹痛、腹胀和排便习惯改变为主要特征的胃肠功能紊乱。肠道菌群失调似乎与该病的发病机制有关。益生菌是一种潜在的治疗方法，因为益生菌可以促进功能性微生物群并改善症状。本研究旨在回顾使用益生菌治疗肠易激综合征症状的效果，分析持续时间和剂量的影响。共纳入了 18 篇文章。就个体而言，乳酸杆菌、双歧杆菌和芽孢杆菌可用于治疗症状。双歧杆菌的效果最好（每天 1 × 109 CFU，持续 4 周）。最有效的组合是 2 株乳酸杆菌、1 株双歧杆菌和 1 株链球菌（4 × 109 CFU/天，4 周）。未来的临床试验应确认这些结果，并分析单独治疗和联合治疗之间的差异。

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Evaluation of the efficacy of probiotics as treatment in irritable bowel syndrome

Irritable bowel syndrome (IBS) is a gastrointestinal functional disorder mainly characterised by abdominal pain, bloating and altered bowel habits. Dysbiosis might seem to be involved in the pathogenesis of the disease. Probiotics represent a potential treatment, since these could favour the functional microbiota and improve symptoms. The aim was to review the effectiveness of the use of probiotics in IBS symptomatology, analysing the influence of duration and dose. 18 articles were included. At the individual level, Lactobacillus, Bifidobacterium and Bacillus could be useful in the treatment of symptoms. Bifidobacterium bifidum reported the best results (1 × 10⁹ CFU/day for 4 weeks). The most effective combination was 2 Lactobacillus strains, one of Bifidobacterium and one of Streptococcus (4 × 10⁹ CFU/day for 4 weeks). Future clinical trials should confirm these results and analyse the difference between individual and combined treatments.

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来源期刊

Endocrinologia Diabetes Y Nutricion Multiple-

CiteScore

2.10

自引率

10.50%

发文量

期刊介绍： Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.