{"title":"角豆树和人参对不育男性精液分析参数、性功能和性激素的影响：双盲随机对照试验研究》。","authors":"Shamim Pilehvari, Seyedeh Zahra Masoumi, Tayebeh G Bahar, Farideh Kazemi, Shirin Moradkhani, Parvin Maleki","doi":"10.4103/ijnmr.ijnmr_460_21","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Infertility is one of the most common problems in the world; there is a growing demand for herbal medicines to treat infertility-related problems.</p><p><strong>Materials and methods: </strong>A randomized controlled trial with three groups was conducted, each with 30 participants. The first group was administered 1.5 grams of Carob daily, the second group was administered 1.5 grams of Ginseng daily, and the third group received a placebo. The treatment was administered for 12 weeks, and before and after the intervention, semen parameters, testosterone, prolactin, luteinizing hormone, follicle-stimulating hormone, thyroid hormones, and sexual function were evaluated. Sexual function was assessed using the International Index of Erectile Function Questionnaire.</p><p><strong>Results: </strong>The mean (SD) age of participants was 34.83 (6.22), 34.60 (5.78), and 33.67 (5.82) years in Carob, Ginseng, and Placebo groups, respectively. The results showed that in the Carob group, the normal volume of semen (Z <sub>133</sub> = 3.05, <i>p</i> = 0.02) and the normal shape of sperm (Z <sub>134</sub> = 2.97, <i>p</i> = 0.01) increased significantly compared to the control group. In the Ginseng group, the normal volume (Z <sub>133</sub> = 3.90, <i>p</i> = 0.001) and the normal viscosity of semen (Z <sub>133</sub> = 2.36, <i>p</i> = 0.01) increased significantly compared to the control group.The Carob group showed a significant increase in normal sperm counts and testosterone hormone levels (Z <sub>131</sub> = 2.81, <i>p</i> = 0.05). The Ginseng group demonstrated a significant improvement in orgasm function (H<sub>2</sub> = 6.14, <i>p</i> = 0.04) and the total score of the International Index of Erectile Function (IIEF) (H<sub>2</sub> = 5.8, <i>p</i> = 0.05).</p><p><strong>Conclusions: </strong>Carob supplements are suggested to enhance some semen parameters and male sex hormones. For infertile men, Ginseng can be beneficial in improving sexual function.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10849286/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of Carob and Ginseng Supplements on Semen Analysis Parameters, Sexual Function, and Sex Hormones in Infertile Men: Double-Blind, Randomized Controlled Trial Study.\",\"authors\":\"Shamim Pilehvari, Seyedeh Zahra Masoumi, Tayebeh G Bahar, Farideh Kazemi, Shirin Moradkhani, Parvin Maleki\",\"doi\":\"10.4103/ijnmr.ijnmr_460_21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Infertility is one of the most common problems in the world; there is a growing demand for herbal medicines to treat infertility-related problems.</p><p><strong>Materials and methods: </strong>A randomized controlled trial with three groups was conducted, each with 30 participants. The first group was administered 1.5 grams of Carob daily, the second group was administered 1.5 grams of Ginseng daily, and the third group received a placebo. The treatment was administered for 12 weeks, and before and after the intervention, semen parameters, testosterone, prolactin, luteinizing hormone, follicle-stimulating hormone, thyroid hormones, and sexual function were evaluated. Sexual function was assessed using the International Index of Erectile Function Questionnaire.</p><p><strong>Results: </strong>The mean (SD) age of participants was 34.83 (6.22), 34.60 (5.78), and 33.67 (5.82) years in Carob, Ginseng, and Placebo groups, respectively. The results showed that in the Carob group, the normal volume of semen (Z <sub>133</sub> = 3.05, <i>p</i> = 0.02) and the normal shape of sperm (Z <sub>134</sub> = 2.97, <i>p</i> = 0.01) increased significantly compared to the control group. In the Ginseng group, the normal volume (Z <sub>133</sub> = 3.90, <i>p</i> = 0.001) and the normal viscosity of semen (Z <sub>133</sub> = 2.36, <i>p</i> = 0.01) increased significantly compared to the control group.The Carob group showed a significant increase in normal sperm counts and testosterone hormone levels (Z <sub>131</sub> = 2.81, <i>p</i> = 0.05). The Ginseng group demonstrated a significant improvement in orgasm function (H<sub>2</sub> = 6.14, <i>p</i> = 0.04) and the total score of the International Index of Erectile Function (IIEF) (H<sub>2</sub> = 5.8, <i>p</i> = 0.05).</p><p><strong>Conclusions: </strong>Carob supplements are suggested to enhance some semen parameters and male sex hormones. For infertile men, Ginseng can be beneficial in improving sexual function.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10849286/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ijnmr.ijnmr_460_21\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijnmr.ijnmr_460_21","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Effect of Carob and Ginseng Supplements on Semen Analysis Parameters, Sexual Function, and Sex Hormones in Infertile Men: Double-Blind, Randomized Controlled Trial Study.
Background: Infertility is one of the most common problems in the world; there is a growing demand for herbal medicines to treat infertility-related problems.
Materials and methods: A randomized controlled trial with three groups was conducted, each with 30 participants. The first group was administered 1.5 grams of Carob daily, the second group was administered 1.5 grams of Ginseng daily, and the third group received a placebo. The treatment was administered for 12 weeks, and before and after the intervention, semen parameters, testosterone, prolactin, luteinizing hormone, follicle-stimulating hormone, thyroid hormones, and sexual function were evaluated. Sexual function was assessed using the International Index of Erectile Function Questionnaire.
Results: The mean (SD) age of participants was 34.83 (6.22), 34.60 (5.78), and 33.67 (5.82) years in Carob, Ginseng, and Placebo groups, respectively. The results showed that in the Carob group, the normal volume of semen (Z 133 = 3.05, p = 0.02) and the normal shape of sperm (Z 134 = 2.97, p = 0.01) increased significantly compared to the control group. In the Ginseng group, the normal volume (Z 133 = 3.90, p = 0.001) and the normal viscosity of semen (Z 133 = 2.36, p = 0.01) increased significantly compared to the control group.The Carob group showed a significant increase in normal sperm counts and testosterone hormone levels (Z 131 = 2.81, p = 0.05). The Ginseng group demonstrated a significant improvement in orgasm function (H2 = 6.14, p = 0.04) and the total score of the International Index of Erectile Function (IIEF) (H2 = 5.8, p = 0.05).
Conclusions: Carob supplements are suggested to enhance some semen parameters and male sex hormones. For infertile men, Ginseng can be beneficial in improving sexual function.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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