协同作用的塞壬之歌

IF 11.5 Q1 HEMATOLOGY

Blood Cancer Discovery Pub Date : 2024-03-01 DOI:10.1158/2643-3230.BCD-24-0004

Patrick D Bhola, Anthony Letai

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引用次数: 0

摘要

摘要：在古希腊神话中，海妖是一种美丽动人的生物，她们神秘的歌声会让水手们把船驶入隐蔽的礁石上，最终一败涂地。在本期杂志中，Mason-Osann 及其同事以急性髓性白血病为背景提供了相关数据，表明虽然协同作用可能会在药物组合中显示出最初的吸引力，但它可能会带来以前未曾预见的危害。参见 Mason-Osann 等人的相关文章(1)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Siren Song of Synergy.

Summary: In ancient Greek mythology, sirens were creatures of stunning beauty whose mystical songs led sailors to sail their boats onto hidden rocks and into total destruction. In this issue, Mason-Osann and colleagues present data in the context of acute myelogenous leukemia to suggest that while synergy may show initial attractions in drug combinations, it may carry with it hazards previously unforeseen. See related article by Mason-Osann et al., p. 95 (1).

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来源期刊

Blood Cancer Discovery Multiple-

CiteScore

12.70

自引率

1.80%

发文量

139

期刊介绍： The journal Blood Cancer Discovery publishes high-quality Research Articles and Briefs that focus on major advances in basic, translational, and clinical research of leukemia, lymphoma, myeloma, and associated diseases. The topics covered include molecular and cellular features of pathogenesis, therapy response and relapse, transcriptional circuits, stem cells, differentiation, microenvironment, metabolism, immunity, mutagenesis, and clonal evolution. These subjects are investigated in both animal disease models and high-dimensional clinical data landscapes. The journal also welcomes submissions on new pharmacological, biological, and living cell therapies, as well as new diagnostic tools. They are interested in prognostic, diagnostic, and pharmacodynamic biomarkers, and computational and machine learning approaches to personalized medicine. The scope of submissions ranges from preclinical proof of concept to clinical trials and real-world evidence. Blood Cancer Discovery serves as a forum for diverse ideas that shape future research directions in hematooncology. In addition to Research Articles and Briefs, the journal also publishes Reviews, Perspectives, and Commentaries on topics of broad interest in the field.