线粒体 Sirtuins：能量动力学与癌症代谢

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules and Cells Pub Date : 2024-02-01 DOI:10.1016/j.mocell.2024.100029

Hojun Lee, Haejin Yoon

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引用次数: 0

摘要

线粒体是能量调节的关键，也与癌症有关。线粒体 sirtuins、SIRT3、SIRT4 和 SIRT5 在癌症代谢中发挥着至关重要的作用。本综述探讨了它们对细胞过程的影响，重点是 NAD+ 的相互作用及其酶活性的调节。概述了 SIRT3、SIRT4 和 SIRT5 在新陈代谢适应和癌症中的不同作用，强调了它们的肿瘤抑制或致癌性质。我们提出了对 sirtuin 生物学和癌症疗法的新见解，建议采用蛋白质组学和代谢组学的综合方法来全面了解线粒体 sirtuin 在癌症中的作用。

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Mitochondrial sirtuins: Energy dynamics and cancer metabolism

Mitochondria are pivotal for energy regulation and are linked to cancer. Mitochondrial sirtuins, (Sirtuin) SIRT3, SIRT4, and SIRT5, play crucial roles in cancer metabolism. This review explores their impact on cellular processes, with a focus on the NAD+ interplay and the modulation of their enzymatic activities. The varied roles of SIRT3, SIRT4, and SIRT5 in metabolic adaptation and cancer are outlined, emphasizing their tumor suppressor or oncogenic nature. We propose new insights into sirtuin biology, and cancer therapeutics, suggesting an integrated proteomics and metabolomics approach for a comprehensive understanding of mitochondrial sirtuins in cancer.

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来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is "Mol. Cells". Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.