天体的洞察力：揭示 miR-3682-3p 在肝细胞癌中的作用。

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2024-04-01 DOI:10.14309/ctg.0000000000000690

Pei-Dong Miao, Ying Li, Yu-Dong Jiang

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引用次数: 0

摘要

肝细胞癌（HCC）仍然是一项严峻的肿瘤挑战，需要创新的治疗策略来改善患者的预后。微RNA（miRNA）已成为癌症的关键调控因子，而miR-3682-3p则显示出作为HCC诊断和预后生物标志物的潜力。我们进行了一项全面的研究，以揭示其在 HCC 生物学中的作用、失调和临床关联。通过靶基因分析，我们了解了潜在的分子机制。此外，我们还探讨了它对肿瘤微环境、免疫细胞浸润和治疗反应的影响。我们的研究结果突显了 miR-3682-3p 是一种有希望在 HCC 治疗中得到进一步研究和潜在治疗策略的候选基因。

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Celestial Insights: Unraveling the Role of miR-3682-3p in Hepatocellular Carcinoma.

Abstract: Hepatocellular carcinoma (HCC) remains a formidable oncological challenge, calling for innovative therapeutic strategies to improve patient outcomes. MicroRNAs have emerged as key regulators in cancer, and miR-3682-3p shows potential as a diagnostic and prognostic biomarker in HCC. We conducted a comprehensive study to uncover its role in HCC biology, revealing dysregulation and clinical associations. Target gene analysis provided insights into potential molecular mechanisms. Moreover, we explored its impact on the tumor microenvironment, immune cell infiltration, and therapy responses. Our findings highlight miR-3682-3p as a promising candidate for further investigations and potential therapeutic strategies in HCC management.

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.