驾驭 Na+-Cl- 共转运体的多面复杂性,它是控制水矿物质平衡的高度调节和关键效应器。

IF 29.9 1区 医学 Q1 PHYSIOLOGY
Physiological reviews Pub Date : 2024-07-01 Epub Date: 2024-02-08 DOI:10.1152/physrev.00027.2023
A V Rioux, T R Nsimba-Batomene, S Slimani, N A D Bergeron, M A M Gravel, S V Schreiber, M J Fiola, L Haydock, A P Garneau, P Isenring
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引用次数: 0

摘要

Na+-Cl- 共转运体(NCC;SLC12A3)是一种高度调节的整体膜蛋白,在灵长类动物中已知有 3 种剪接变体。它在肾脏中的主要作用是介导 Na+ 和 Cl- 跨远端曲小管顶端膜的共转运。通过这一作用以及其他离子转运系统的参与,NCC 允许全身循环回收一部分超滤的 Na+、K+、Cl- 和 Mg+,以交换 Ca2+ 和 HCO3-。人体 Na+-Cl- 共转运机制的生理意义体现在服用噻嗪类药物或因遗传性疾病导致 NCC 失活而出现的一些异常现象。本综述的目的是讨论 Na+-Cl- 共转运的分子机制和整体作用,这是我们感兴趣的主要话题。在阅读所提出的叙述时,人们会意识到,无论现在的知识多么精炼,有关这些主题的知识仍将不断进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Navigating the multifaceted intricacies of the Na+-Cl- cotransporter, a highly regulated key effector in the control of hydromineral homeostasis.

The Na+-Cl- cotransporter (NCC; SLC12A3) is a highly regulated integral membrane protein that is known to exist as three splice variants in primates. Its primary role in the kidney is to mediate the cosymport of Na+ and Cl- across the apical membrane of the distal convoluted tubule. Through this role and the involvement of other ion transport systems, NCC allows the systemic circulation to reclaim a fraction of the ultrafiltered Na+, K+, Cl-, and Mg+ loads in exchange for Ca2+ and [Formula: see text]. The physiological relevance of the Na+-Cl- cotransport mechanism in humans is illustrated by several abnormalities that result from NCC inactivation through the administration of thiazides or in the setting of hereditary disorders. The purpose of the present review is to discuss the molecular mechanisms and overall roles of Na+-Cl- cotransport as the main topics of interest. On reading the narrative proposed, one will realize that the knowledge gained in regard to these themes will continue to progress unrelentingly no matter how refined it has now become.

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来源期刊
Physiological reviews
Physiological reviews 医学-生理学
CiteScore
56.50
自引率
0.90%
发文量
53
期刊介绍: Physiological Reviews is a highly regarded journal that covers timely issues in physiological and biomedical sciences. It is targeted towards physiologists, neuroscientists, cell biologists, biophysicists, and clinicians with a special interest in pathophysiology. The journal has an ISSN of 0031-9333 for print and 1522-1210 for online versions. It has a unique publishing frequency where articles are published individually, but regular quarterly issues are also released in January, April, July, and October. The articles in this journal provide state-of-the-art and comprehensive coverage of various topics. They are valuable for teaching and research purposes as they offer interesting and clearly written updates on important new developments. Physiological Reviews holds a prominent position in the scientific community and consistently ranks as the most impactful journal in the field of physiology.
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