来自 Aureobasidium pullulans 的三种新的 griseofulvin 衍生物。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-07-03 DOI:10.1080/14786419.2024.2312428

Jian-Hua Lv , Lan Yao , Shi-Yu Li , Ming-Yu Ye , Dan Li , Chang-Tian Li , Yu Li

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引用次数: 0

摘要

从 Aureobasidium pullulans 固体发酵产物的乙酸乙酯萃取物中分离出了三种新的鬼臼毒素衍生物，即鬼臼毒素苷 A-C（1-3）。通过大量的 MS、1D 和 2D NMR 光谱数据分析，阐明了它们的结构。体外评估了新化合物对四种植物病原真菌的抗真菌活性，所有测试化合物均表现出抑制作用。其中，化合物 2 对所选的四种植物病原真菌的活性最强，在 0.2 毫克/毫升的浓度下，抑制率为 40.2% 至 75.8%。

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Three new griseofulvin derivatives from Aureobasidium pullulans

Three new griseofulvin derivatives, griseofulvinoside A-C (1-3), were isolated from the ethyl acetate extract of the solid fermentation product of Aureobasidium pullulans. Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR. The antifungal activities of new compounds were evaluated against four phytopathogenic fungi in vitro, and all test compounds demonstrated inhibitory effects. Among them, compound 2 exhibited the most potent activities against the four selected phytopathogenic fungi with inhibitory rates ranging from 40.2 to 75.8% at 0.2 mg/mL.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.