环境富集对受到矛头蝮威胁的雄性小鼠具有类似恐慌症的作用

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Bruno Mangili de Paula Rodrigues, Luiz Luciano Falconi-Sobrinho, Alline Cristina de Campos, Alexandre Kanashiro, Norberto Cysne Coimbra
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引用次数: 0

摘要

环境强化(EE)是一种众所周知的减压模式,对不同的精神疾病都有好处,但其对惊恐障碍的积极作用尚未得到证实。猎物和捕食者在复杂环境中的对抗已被证实是一种可能的惊恐发作模型。这项工作的主要目的是研究 EE 对受到毒蛇威胁的小鼠所引起的类似恐慌的防御反应的作用。在富集环境或标准环境中暴露 6 周后,36 只雄性小鼠在一个包含人工洞穴和高架逃生平台的复杂多边形蛇场中习性化。小鼠与蛇对峙 5 分钟,并记录了以下反捕食反应:防御性注意、伸展随从姿势、平背接近、猎物与捕食者之间的互动、定向逃跑行为、在安全地点停留的时间以及穿越的次数。受到蛇威胁的小鼠表现出的几种反捕食反应与在相同环境中受到无威胁情况(玩具蛇)的小鼠的探索行为相比有很大不同。值得注意的是,EE 会引起类似抗焦虑和恐慌的效应,显著减少防御性注意和在安全场所停留的时间,并显著增加猎物与捕食者之间的互动和探索行为。总之,我们的数据表明,在危险条件下,EE 可以改变对焦虑和恐慌类反应的恐惧调节处理,从而显著改变决策防御策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Panicolytic-like effects of environment enrichment on male mice threatened by Bothrops jararaca lancehead pit vipers

Environment enrichment (EE) is a well-known eustress model showing beneficial effects in different psychiatric diseases, but its positive properties in panic disorders are not yet established. The confrontation between prey and predator in complex arenas has been validated as a putative panic attack model. The principal aim of this work was to investigate the role of the EE on panic-like defensive responses elicited by mice threatened by venomous snakes. After 6 weeks of exposure either to an enriched or standard environments, 36 male mice were habituated in a complex polygonal arena for snakes containing an artificial burrow and elevated platforms for escape. The animals were confronted by Bothrops jararaca for 5 min, and the following antipredatory responses were recorded: defensive attention, stretched attend posture, flat back approach, prey versus predator interaction, oriented escape behavior, time spent in a safe place, and number of crossings. Mice threatened by snakes displayed several antipredatory reactions as compared to the exploratory behavior of those animals submitted to a nonthreatening situation (toy snake) in the same environment. Notably, EE causes anxiolytic- and panicolytic-like effects significantly decreasing the defensive attention and time spent in safe places and significantly increasing both prey versus predator interaction and exploratory behavior. In conclusion, our data demonstrate that EE can alter the processing of fear modulation regarding both anxiety- and panic-like responses in a dangerous condition, significantly modifying the decision-making defensive strategy.

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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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