广泛的靶向定量脂质组学揭示了长期接触双酚 A 和果糖后脂肪组织的脂质重塑。

Yonghong Tang, Guifang Ou, Ouyan Rang, Xu Liu, Xiaocheng Liu, Xinru Qin, Guojuan Li, Qing Yang, Mu Wang
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引用次数: 0

摘要

脂肪组织是储存脂质的主要器官,在体内新陈代谢平衡中发挥着重要作用。我们最近在《人类与实验毒理学》(Human and Experimental Toxicology)杂志上报道,同时接触双酚 A 和果糖可能会干扰脂肪组织的能量代谢。然而,目前还不清楚双酚 A 和果糖的联合暴露是否有可能诱导脂肪组织的脂质重塑。在本研究中,我们对双酚 A 和果糖联合暴露 6 个月后的大鼠脂肪组织进行了广泛的定向定量脂质体分析。我们总共测定了大鼠脂肪组织中的 734 种脂质分子。主成分分析(PCA)结果表明,较高剂量(25 μg/kg,隔日一次)双酚A和果糖联合暴露组与对照组、较高剂量双酚A暴露组和果糖暴露组有明显的区别。偏最小二乘判别分析(PLS-DA)和单变量统计分析显示,PC(18:0_ 20:3)、TG(8:0_14:0_16:0)、TG(12:0_14:0_16:1)、TG(10:0_16:0_16:1)、TG(12:0_ 14:0_18:1)、TG(14:0_16:0_16:1)、TG(14:0_14:1_16:1)、TG(8:0_16:1_16:2)、TG(14:1_16:1_16:1)、TG(16:1_18:1_18:1)、TG(16:0_16:1_20:4)和 TG(15:0_18:1_24:1)可能对分辨作用最大。这些研究结果表明,同时接触双酚 A 和果糖有可能导致脂肪组织的脂质重塑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Widely targeted quantitative lipidomics reveal lipid remodeling in adipose tissue after long term of the combined exposure to bisphenol A and fructose.

Adipose tissue is the main organ that stores lipids and it plays important roles in metabolic balance in the body. We recently reported in Human and Experimental Toxicology that the combined exposure to BPA and fructose may interfere with energy metabolism of adipose tissue. However, it is still unclear whether the combined exposure to BPA and fructose has the possibility to induce lipid remodeling in adipose tissue. In the present study, we performed a widely targeted quantitative lipidomic analysis of the adipose tissue of rats after 6 months of BPA and fructose combined exposure. We totally determined 734 lipid molecules in the adipose tissue of rats. Principal component analysis (PCA) showed the group of the combined exposure to higher-dose (25 μg/kg every other day) BPA and fructose can be distinguished from the groups of control, higher-dose BPA exposure and fructose exposure clearly. Partial least squares-discriminant analysis (PLS-DA) and univariate statistical analysis displayed lipids of PC(18:0_ 20:3), TG(8:0_14:0_16:0), TG(12:0_14:0_16:1), TG(10:0_16:0_16:1), TG(12:0_ 14:0_18:1), TG(14:0_ 16:0_16:1), TG(14:0_14:1_16:1), TG(8:0_ 16:1_16:2), TG(14:1_16:1_ 16:1), TG(16:1_18:1_18:1), TG(16:0_16:1_20:4) and TG(15:0_18:1_ 24:1) may contributed the most to the discrimination. These findings indicated that combined exposure to BPA and fructose has the potential to cause lipid remodeling in adipose tissue.

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