{"title":"综述甲基苯丙胺对新物体识别的干扰","authors":"Seyedeh Masoumeh Seyedhosseini Tamijani, Elmira Beirami, Hamed Ghazvini, Raheleh Rafaiee, Masoud Nazeri, Moazamehosadat Razavinasab","doi":"10.34172/ahj.2023.1307","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Methamphetamine (MA), is a widely abused synthetic psychostimulant that leads to irreversible brain damage manifested as cognitive impairments in humans and animals. The novel object recognition (NOR) task is a commonly used behavioral assay for the investigation of non-spatial memory in rodents. This test is based on the natural tendency of rodents to spend more time exploring a novel object than a familiar one. NOR test has been used in many studies investigating cognitive deficits caused by MA in rodents. The objective of the present study was to review neurobiological mechanisms that might be responsible for MA-induced NOR alterations.</p><p><strong>Methods: </strong>A PubMed search showed 83 publications using novel object recognition and methamphetamine as keywords in the past 10 years.</p><p><strong>Findings: </strong>The present study revealed different MA regimens cause recognition memory impairment in rodents. In addition, it was found that the main neurobiological mechanism involved in MA-induced recognition deficits is the dysfunction of monoaminergic systems.</p><p><strong>Conclusion: </strong>NOR is a useful test to assess the cognitive functions following MA administration and evaluate the efficacy of new therapeutic agents in MA-addicted individuals.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"15 4","pages":"289-297"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843358/pdf/","citationCount":"0","resultStr":"{\"title\":\"A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine.\",\"authors\":\"Seyedeh Masoumeh Seyedhosseini Tamijani, Elmira Beirami, Hamed Ghazvini, Raheleh Rafaiee, Masoud Nazeri, Moazamehosadat Razavinasab\",\"doi\":\"10.34172/ahj.2023.1307\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Methamphetamine (MA), is a widely abused synthetic psychostimulant that leads to irreversible brain damage manifested as cognitive impairments in humans and animals. The novel object recognition (NOR) task is a commonly used behavioral assay for the investigation of non-spatial memory in rodents. This test is based on the natural tendency of rodents to spend more time exploring a novel object than a familiar one. NOR test has been used in many studies investigating cognitive deficits caused by MA in rodents. The objective of the present study was to review neurobiological mechanisms that might be responsible for MA-induced NOR alterations.</p><p><strong>Methods: </strong>A PubMed search showed 83 publications using novel object recognition and methamphetamine as keywords in the past 10 years.</p><p><strong>Findings: </strong>The present study revealed different MA regimens cause recognition memory impairment in rodents. In addition, it was found that the main neurobiological mechanism involved in MA-induced recognition deficits is the dysfunction of monoaminergic systems.</p><p><strong>Conclusion: </strong>NOR is a useful test to assess the cognitive functions following MA administration and evaluate the efficacy of new therapeutic agents in MA-addicted individuals.</p>\",\"PeriodicalId\":33943,\"journal\":{\"name\":\"Addiction and Health\",\"volume\":\"15 4\",\"pages\":\"289-297\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843358/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Addiction and Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34172/ahj.2023.1307\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/10/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Addiction and Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/ahj.2023.1307","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/29 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景：甲基苯丙胺（MA）是一种广泛滥用的合成精神兴奋剂，可导致不可逆的脑损伤，表现为人类和动物的认知障碍。新物体识别（NOR）任务是研究啮齿类动物非空间记忆的常用行为试验。该测试基于啮齿类动物花更多时间探索新物体而非熟悉物体的自然倾向。NOR测试已被用于许多调查啮齿动物MA导致的认知缺陷的研究中。本研究的目的是回顾可能导致 MA 引起的 NOR 改变的神经生物学机制：方法：在PubMed上搜索发现，过去10年中有83篇论文使用了新物体识别和甲基苯丙胺作为关键词：本研究发现，不同的甲基苯丙胺治疗方案会导致啮齿动物识别记忆受损。此外，研究还发现，甲基苯丙胺诱发识别障碍的主要神经生物学机制是单胺能系统功能障碍：结论：NOR是一项有用的测试，可用于评估服用MA后的认知功能，以及评估新治疗药物对MA成瘾者的疗效。
A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine.
Background: Methamphetamine (MA), is a widely abused synthetic psychostimulant that leads to irreversible brain damage manifested as cognitive impairments in humans and animals. The novel object recognition (NOR) task is a commonly used behavioral assay for the investigation of non-spatial memory in rodents. This test is based on the natural tendency of rodents to spend more time exploring a novel object than a familiar one. NOR test has been used in many studies investigating cognitive deficits caused by MA in rodents. The objective of the present study was to review neurobiological mechanisms that might be responsible for MA-induced NOR alterations.
Methods: A PubMed search showed 83 publications using novel object recognition and methamphetamine as keywords in the past 10 years.
Findings: The present study revealed different MA regimens cause recognition memory impairment in rodents. In addition, it was found that the main neurobiological mechanism involved in MA-induced recognition deficits is the dysfunction of monoaminergic systems.
Conclusion: NOR is a useful test to assess the cognitive functions following MA administration and evaluate the efficacy of new therapeutic agents in MA-addicted individuals.
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