潜入紫杉醇：从西苏门答腊 Singgalang 保护中心的苏门答腊紫杉（Taxus sumatrana）中分离和筛选内容。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-19 DOI:10.1080/14786419.2024.2312540

Rahmat Kurniawan , Sukrasno Sukrasno , Arif Ashari , Tati Suhartati

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引用次数: 0

摘要

该报告首次从受保护的苏门答腊紫杉（Taxus sumatrana）木材中分离出紫杉醇。苏门答腊紫杉是一种受国家保护的特有植物，已在西苏门答腊 Singgalang 保护中心的自然栖息地外成功栽培。紫杉醇被用作评估苏门答腊树不同部位中紫杉醇含量的参考标准。分析表明，苏门答腊树皮丙酮提取物中的紫杉醇浓度最高，约为 0.473 ± 0.031 ppm。分离出的紫杉醇对 A549、HeLa 和 MCF7 癌细胞具有很强的细胞毒性，IC50 值分别为 3.26 ± 0.334、2.85 ± 0.257 和 3.81 ± 0.013 μM。这一结果为保护计划和社区参与保护工作的运动提供了科学支持。

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Diving into paclitaxel: isolation and screening content from Taxus sumatrana at Singgalang Conservation Center, West Sumatra

The report features the first isolation of paclitaxel from wood of conservated Taxus sumatrana. The T. sumatrana is a nationally protected endemic plant that has been successfully cultivated outside its natural habitat at the Singgalang Conservation Centre in West Sumatra. The paclitaxel was utilised as a reference standard for evaluating its presence in different parts of T. sumatrana. This analysis exhibits that the acetone extract from T. sumatrana bark contained the highest paclitaxel concentration, measuring about 0.473 ± 0.031 ppm. The isolated paclitaxel demonstrated potent cytotoxic activity against A549, HeLa, and MCF7 cancer cells, by IC₅₀ values of 3.26 ± 0.334, 2.85 ± 0.257, and 3.81 ± 0.013 μM, respectively. This outcome provides scientific support for conservation programs and campaigns for the community to engage in conservation efforts.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.