Carlina Leila Colussi, Guillaume Martinez, Jean-Philippe Bellenger, Gisela Laura Poletta, María Fernanda Simoniello
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The monitoring of genotoxic effects in different populations is a useful tool in human biomonitoring and has great biological importance in estimating the exposure risks to complex mixtures of chemical substances.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study aimed to determine the presence of environmental xenobiotics and evaluate their genotoxic effect, in mothers of newborns with and without CA, and the possible association/correlation between those biomarkers and CA.</p>\n </section>\n \n <section>\n \n <h3> Materials and methods</h3>\n \n <p>A descriptive case and control cross-sectional study was developed on 290 postpartum women from Santa Fe, Argentina.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Significant differences were observed between both groups, for places of residence and gynecological variables. Metabolites of organochlorine (OC), organophosphate (OP), and pyrethroid (PYR) pesticides were detected. 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引用次数: 0
摘要
引言 先天性畸形（CA）的流行病学调查是一项挑战，因为相关的风险因素，尤其是环境因素具有多重性。监测不同人群的基因毒性效应是人类生物监测的有用工具，对于估计接触复杂混合化学物质的风险具有重要的生物学意义。 本研究旨在确定患有和未患有 CA 的新生儿母亲体内是否存在环境异种生物，并评估其基因毒性效应，以及这些生物标志物与 CA 之间可能存在的关联/相关性。 材料和方法 对阿根廷圣菲的 290 名产后妇女进行了一项描述性病例和对照横断面研究。 结果 观察到两组妇女在居住地和妇科变量方面存在显著差异。检测到了有机氯（OC）、有机磷（OP）和拟除虫菊酯（PYR）农药的代谢物。最常检测到的化合物是阿特拉津（ATZ）（57.14%）、多菌灵（CBZ）（46.42%）和甲基对硫磷（46.42%）等。血液中农药的数量与基因毒性变量之间呈正相关。另一方面，泌尿生殖系统异常儿童的母亲体内 ATZ 和 OP 的浓度最高。 讨论与结论 这些结果表明，圣达菲的健康现实有着深厚的背景，这可能会对早产儿未来成人的健康产生极大的影响。另一方面，检测到的杀虫剂混合物证实了妇女的生活环境条件以及每次怀孕时胎盘暴露于这些化合物的情况。对后代长期健康的潜在影响是未知的，也是不可预测的。
Prenatal exposure to pesticide mixture in Argentina: A pilot study in puerperal women from Santa Fe province
Introduction
The epidemiological investigation of congenital anomalies (CA) represents a challenge due to the multiplicity of associated risk factors, notably environmental ones. The monitoring of genotoxic effects in different populations is a useful tool in human biomonitoring and has great biological importance in estimating the exposure risks to complex mixtures of chemical substances.
Objective
This study aimed to determine the presence of environmental xenobiotics and evaluate their genotoxic effect, in mothers of newborns with and without CA, and the possible association/correlation between those biomarkers and CA.
Materials and methods
A descriptive case and control cross-sectional study was developed on 290 postpartum women from Santa Fe, Argentina.
Results
Significant differences were observed between both groups, for places of residence and gynecological variables. Metabolites of organochlorine (OC), organophosphate (OP), and pyrethroid (PYR) pesticides were detected. The most frequently detected compounds were atrazine (ATZ) (57.14%), carbendazim (CBZ) (46.42%), and methylparaben (46.42%), among others. A positive correlation was found between the number of pesticides in blood and genotoxic variables. On the other hand, mothers of children with genitourinary anomalies were the ones with the highest concentrations of ATZ and OP.
Discussion and conclusion
These results showed a deep background in the health reality of Santa Fe, which could greatly impact the health of future adults, who have been born preterm. On the other hand, the mixture of pesticides detected confirms the environmental living conditions of women and the transplacental exposure to these compounds in each pregnancy. The potential effects on long-term descendent health are unknown and unpredictable.
期刊介绍：
The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks.
Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.
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