目前对肠杆菌素调控的理解。

IF 2.6 4区生物学 Q3 MICROBIOLOGY

Microbiology-Sgm Pub Date : 2024-02-01 DOI:10.1099/mic.0.001427

Emily Addington, Sofia Sandalli, Andrew J Roe

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引用次数: 0

摘要

B2 系统群中的许多大肠杆菌都有一个 pks 致病性岛，该致病性岛中的 19 个基因（clbA - S）编码了生产大肠菌素的生物合成机制。高半乳糖烯是一种强效的基因毒性代谢物，可导致 DNA 损伤，并在微生物竞争和 pks+ 细菌的适应性方面发挥潜在作用。大肠菌素还与大肠癌的发生密切相关。鉴于高半乳糖烯的基因毒性及其合成的代谢成本，管理 clb 簇的调控系统也相应地非常复杂，其中许多机制仍有待阐明。在这篇综述中，我们总结了目前对内部分子成分调控大肠菌素生物合成以及这些因素如何受外部环境信号调节的理解。

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Current understandings of colibactin regulation.

The biosynthetic machinery for the production of colibactin is encoded by 19 genes (clbA - S) within the pks pathogenicity island harboured by many E. coli of the B2-phylogroup. Colibactin is a potent genotoxic metabolite which causes DNA-damage and which has potential roles in microbial competition and fitness of pks+ bacteria. Colibactin has also been strongly implicated in the development of colorectal cancer. Given the genotoxicity of colibactin and the metabolic cost of its synthesis, the regulatory system governing the clb cluster is accordingly highly complex, and many of the mechanisms remain to be elucidated. In this review we summarise the current understanding of regulation of colibactin biosynthesis by internal molecular components and how these factors are modulated by signals from the external environment.

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来源期刊

Microbiology-Sgm 生物-微生物学

CiteScore

4.60

自引率

7.10%

发文量

132

审稿时长

3.0 months

期刊介绍： We publish high-quality original research on bacteria, fungi, protists, archaea, algae, parasites and other microscopic life forms. Topics include but are not limited to: Antimicrobials and antimicrobial resistance Bacteriology and parasitology Biochemistry and biophysics Biofilms and biological systems Biotechnology and bioremediation Cell biology and signalling Chemical biology Cross-disciplinary work Ecology and environmental microbiology Food microbiology Genetics Host–microbe interactions Microbial methods and techniques Microscopy and imaging Omics, including genomics, proteomics and metabolomics Physiology and metabolism Systems biology and synthetic biology The microbiome.