Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar
{"title":"2017 年至 2019 年印度各地角结膜炎流行病学：一项基于医院的多中心研究。","authors":"Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar","doi":"10.1080/09286586.2023.2301572","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Conjunctivitis is one of the most common ocular conditions in clinical practice. Human adenoviruses have been the common causative agents known to cause epidemic kerato-conjunctivitis (EKC) in India from 1996 to 2019 with a positivity range of 13.8%-65.2%. The current study was initiated to throw light on the distribution of keratoconjunctivitis causing agents across India covering a span of 3 years.</p><p><strong>Methods: </strong>A total of 709 swabs were collected from patients in viral transport medium (VTM), and real-time PCR was done to identify agents including Adenovirus (HAdV), Enterovirus, HSV, and Chlamydia.</p><p><strong>Results: </strong>47.8% of the samples were positive for HAdV followed by HSV (3.4%), Enterovirus (2.7%), and Chlamydia (0.6%). Overall, 386 people (54.4%) tested positive for one of these infections, with Chandigarh (88.4%) and Port Blair (71.7%) showing higher positivity rate. Pre-auricular lymphadenopathy and follicles were significantly associated with increased risk of conjunctivitis.</p><p><strong>Conclusion: </strong>Epidemiology of keratoconjunctivitis in the current study revealed HAdV to be predominant causative agent. Knowledge gained in such epidemiological studies guide us in outbreak expectations, limit antibiotic over-prescription, and enhance disease prevention.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"439-447"},"PeriodicalIF":16.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epidemiology of Keratoconjunctivitis Across India from 2017 to 2019: A Multicentric Hospital-Based Study.\",\"authors\":\"Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar\",\"doi\":\"10.1080/09286586.2023.2301572\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Conjunctivitis is one of the most common ocular conditions in clinical practice. 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Epidemiology of Keratoconjunctivitis Across India from 2017 to 2019: A Multicentric Hospital-Based Study.
Purpose: Conjunctivitis is one of the most common ocular conditions in clinical practice. Human adenoviruses have been the common causative agents known to cause epidemic kerato-conjunctivitis (EKC) in India from 1996 to 2019 with a positivity range of 13.8%-65.2%. The current study was initiated to throw light on the distribution of keratoconjunctivitis causing agents across India covering a span of 3 years.
Methods: A total of 709 swabs were collected from patients in viral transport medium (VTM), and real-time PCR was done to identify agents including Adenovirus (HAdV), Enterovirus, HSV, and Chlamydia.
Results: 47.8% of the samples were positive for HAdV followed by HSV (3.4%), Enterovirus (2.7%), and Chlamydia (0.6%). Overall, 386 people (54.4%) tested positive for one of these infections, with Chandigarh (88.4%) and Port Blair (71.7%) showing higher positivity rate. Pre-auricular lymphadenopathy and follicles were significantly associated with increased risk of conjunctivitis.
Conclusion: Epidemiology of keratoconjunctivitis in the current study revealed HAdV to be predominant causative agent. Knowledge gained in such epidemiological studies guide us in outbreak expectations, limit antibiotic over-prescription, and enhance disease prevention.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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