Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar
{"title":"2017 年至 2019 年印度各地角结膜炎流行病学：一项基于医院的多中心研究。","authors":"Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar","doi":"10.1080/09286586.2023.2301572","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Conjunctivitis is one of the most common ocular conditions in clinical practice. Human adenoviruses have been the common causative agents known to cause epidemic kerato-conjunctivitis (EKC) in India from 1996 to 2019 with a positivity range of 13.8%-65.2%. The current study was initiated to throw light on the distribution of keratoconjunctivitis causing agents across India covering a span of 3 years.</p><p><strong>Methods: </strong>A total of 709 swabs were collected from patients in viral transport medium (VTM), and real-time PCR was done to identify agents including Adenovirus (HAdV), Enterovirus, HSV, and Chlamydia.</p><p><strong>Results: </strong>47.8% of the samples were positive for HAdV followed by HSV (3.4%), Enterovirus (2.7%), and Chlamydia (0.6%). Overall, 386 people (54.4%) tested positive for one of these infections, with Chandigarh (88.4%) and Port Blair (71.7%) showing higher positivity rate. Pre-auricular lymphadenopathy and follicles were significantly associated with increased risk of conjunctivitis.</p><p><strong>Conclusion: </strong>Epidemiology of keratoconjunctivitis in the current study revealed HAdV to be predominant causative agent. Knowledge gained in such epidemiological studies guide us in outbreak expectations, limit antibiotic over-prescription, and enhance disease prevention.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"439-447"},"PeriodicalIF":1.7000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epidemiology of Keratoconjunctivitis Across India from 2017 to 2019: A Multicentric Hospital-Based Study.\",\"authors\":\"Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar\",\"doi\":\"10.1080/09286586.2023.2301572\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Conjunctivitis is one of the most common ocular conditions in clinical practice. 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Epidemiology of Keratoconjunctivitis Across India from 2017 to 2019: A Multicentric Hospital-Based Study.
Purpose: Conjunctivitis is one of the most common ocular conditions in clinical practice. Human adenoviruses have been the common causative agents known to cause epidemic kerato-conjunctivitis (EKC) in India from 1996 to 2019 with a positivity range of 13.8%-65.2%. The current study was initiated to throw light on the distribution of keratoconjunctivitis causing agents across India covering a span of 3 years.
Methods: A total of 709 swabs were collected from patients in viral transport medium (VTM), and real-time PCR was done to identify agents including Adenovirus (HAdV), Enterovirus, HSV, and Chlamydia.
Results: 47.8% of the samples were positive for HAdV followed by HSV (3.4%), Enterovirus (2.7%), and Chlamydia (0.6%). Overall, 386 people (54.4%) tested positive for one of these infections, with Chandigarh (88.4%) and Port Blair (71.7%) showing higher positivity rate. Pre-auricular lymphadenopathy and follicles were significantly associated with increased risk of conjunctivitis.
Conclusion: Epidemiology of keratoconjunctivitis in the current study revealed HAdV to be predominant causative agent. Knowledge gained in such epidemiological studies guide us in outbreak expectations, limit antibiotic over-prescription, and enhance disease prevention.
期刊介绍：
Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.
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