基于纳米双锥金的激光激活密封剂可有效密封和修复皮肤。

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-02-06 DOI:10.1080/02656736.2023.2301035
Shubham Pallod, Gareth Fuller, Trishita Chowdhury, Kaushal Rege
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引用次数: 0

摘要

各向异性金纳米结构因其卓越的光学特性,在生物医学应用中日益受到关注。与传统的金纳米颗粒相比,一种新兴的金纳米结构--金纳米双锥体(AuNBP)--已被证明具有更优越的吸收特性,这使它们在光热应用中具有吸引力。我们采用种子介导法生成了高纯度的 AuNBP 分散体,并将其作为光热转换剂嵌入蚕丝纤维素基质中,以研究它们在免疫功能正常的小鼠切口光热密封中的功效。这些掺杂了 AuNBP 的激光激活密封剂或 AuNBP-LASE 能够吸收近红外激光能量并将其转化为热量,从而在伤口和周围组织中诱导瞬时高热。这种光热转换促进了 AuNBP-LASE 对皮肤组织的快速密封,与尼龙缝合线相比,在修复的早期阶段,皮肤屏障功能恢复得更快。此外,与缝合切口相比,AuNBP-LASE 能更快地封闭愈合皮肤的生物力学特性。组织学研究表明,与传统缝合相比,LASE 在皮肤组织切口内的渗透率更高,结痂形成更少,表皮间隙相似。这些结果表明,AuNBP-LASE 可作为光热密封的伤口近似装置。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gold nanobipyramids-based laser-activated sealants for effective skin sealing and repair.

Anisotropic gold nanostructures have gained increased attention for biomedical applications because of their remarkable optical properties. An emerging type of gold nanostructure-gold nanobipyramids (AuNBP)-has been shown to exhibit superior absorption properties compared to conventionally used gold nanoparticles, which makes them attractive for photothermal applications. We generated a high-shape-purity dispersion of AuNBP using a seed-mediated method and embedded them as photothermal conversion agents in a silk fibroin matrix to investigate their efficacy in photothermal sealing of incisional wounds in immunocompetent mice. These AuNBP-doped laser-activated sealants, or AuNBP-LASE were able to absorb near-infrared laser energy and convert it to heat, thereby inducing transient hyperthermia in the wound and the surrounding tissue. This photothermal conversion facilitated rapid sealing of the skin tissue by the AuNBP-LASE, which resulted in faster functional recovery of skin barrier function compared to nylon sutures at the early stages of repair. Further, the biomechanical properties of the healing skin closed with AuNBP-LASE those of intact skin more rapidly compared to incisions approximated with sutures. Histology studies indicated higher penetration of the LASE within the volume of the incision in skin tissue, lower scab formation, and a similar epidermal gap compared to conventional suturing. These results demonstrate that AuNBP-LASEs can be effective as wound approximation devices for photothermal sealing.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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