锌转运体 ZnT1 mRNA 表达与瘦素血清浓度呈负相关,但与内脏脂肪组织中的胰岛素抵抗或炎症标志物无关。

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biological Trace Element Research Pub Date : 2024-12-01 Epub Date: 2024-02-06 DOI:10.1007/s12011-024-04089-5
Ana Karen Torres-Arreola, Olga P García, Paulina Estrella-Ibarra, Francisco Campos-Maldonado, Mariela Camacho-Barron, María Del Carmen Aburto-Fernández, Ricardo Martín Lerma-Alvarado, Adriana Jheny Rodriguez-Méndez, Juan Carlos Solís-Sáinz, Pablo García-Solís
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引用次数: 0

摘要

本研究旨在评估慢性炎症生物标志物、胰岛素抵抗和锌转运体 ZnT1 在人体内脏脂肪组织中的表达之间的关系。研究人员从 47 名接受腹腔镜胆囊切除术的成年人体内获取了内脏脂肪组织,通过 RT-qPCR 分析了 ZnT1 mRNA 的表达。比较了正常体重、超重和肥胖受试者的 ZnT1 mRNA 水平。与体重正常的受试者相比,超重和肥胖受试者的 ZnT1 表达量明显较低(p = 0.0016)。此外,体重正常者的血清锌浓度(97.7 ± 13.1 mg/L)明显高于超重者(87.0 ± 12.8 mg/L)和肥胖者(83.1 ± 6.6 mg/L)(p = 0.002)。皮尔逊检验显示,血清锌浓度与内脏脂肪组织中 ZnT1 mRNA 的表达呈正相关(r = 0.323;p = 0.031),与体重指数呈负相关(r = - 0.358;p = 0.013)。采用线性回归模型分析了 ZnT1 mRNA 表达与血清锌水平、胰岛素抵抗(HOMA2-IR)、血清脂肪因子(瘦素和脂肪连通素)和血清炎症生物标志物(肿瘤坏死因子α、白细胞介素-6 和 C 反应蛋白)之间的关系。有趣的是,瘦素浓度与 ZnT1 mRNA 表达呈负相关(p = 0.012);然而,在其他分析变量中未发现显著的相关性。未来的研究需要分析内脏脂肪组织中 ZntT1 表达与瘦素之间负相关的因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Zinc Transporter ZnT1 mRNA Expression Is Negatively Associated with Leptin Serum Concentrations but Is not Associated with Insulin Resistance or Inflammatory Markers in Visceral Adipose Tissue.

The aim of this study was to evaluate the relationship between biomarkers of chronic inflammation, insulin resistance, and zinc transporter ZnT1 expression in human visceral adipose tissue. Visceral adipose tissue obtained from 47 adults undergoing laparoscopic surgery for cholecystectomy was used to analyze ZnT1 mRNA expression by RT-qPCR. ZnT1 mRNA levels were compared between subjects with normal weight, overweight, and obesity. A significantly lower ZnT1 expression was observed in overweight and obesity compared with normal-weight subjects (p = 0.0016). Moreover, subjects with normal weight had significantly higher serum zinc concentration (97.7 ± 13.1 mg/L) than subjects with overweight (87.0 ± 12.8 mg/L) and obesity (83.1 ± 6.6 mg/L) (p = 0.002). Pearson test showed a positive correlation between serum zinc concentrations and ZnT1 mRNA expression in visceral adipose tissue (r = 0.323; p = 0.031) and a negative correlation with body mass index (r =  - 0.358; p = 0.013). A linear regression model was used to analyze the associations between ZnT1 mRNA expression and serum zinc levels, insulin resistance (HOMA2-IR), serum adipokines (leptin and adiponectin), and serum inflammation biomarkers (tumor necrosis factor alpha, interleukin-6, and C-reactive protein). Interestingly, leptin concentrations were negatively associated with ZnT1 mRNA expression (p = 0.012); however, no significant associations were found for the rest of the analyzed variables. Future research is needed to analyze the causality of negative association between ZntT1 expression in visceral adipose tissue and leptin.

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来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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