右侧背外侧前额叶皮层的 Theta 振荡对言语和肢体抑制的作用不同

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Karim Johari, Joel I. Berger
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引用次数: 0

摘要

有证据表明,语言和肢体运动抑制有共同的神经机制,特别是在右侧前额叶皮层。在最近的一项研究中,我们发现对右侧背外侧前额叶皮层(rDLPFC)的阴极刺激对言语和肢体抑制的 P3 事件相关电位有不同的调节作用。在本研究中,我们进一步分析了这些数据,研究了在 21 名神经畸形成人的 Go/No-Go 任务中,对 rDLPFC 进行阴极高清晰度经颅直流电刺激(HD-tDCS)对认知控制的振荡标记--额叶 theta 的影响。脑电图数据显示,言语和肢体No-Go都会在右前额叶电极上引起明显的θ活动,与肢体相比,言语的活动更强。此外,我们还发现阴极刺激能显著增加语音和肢体No-Go时右侧前额叶电极上的θ功率。源分析表明,与肢体运动抑制相比,阴极刺激能增加言语 "不走 "时 rDLPFC 和双侧前运动皮层内的 Theta 活动,而假刺激则不能。这些发现补充了我们之前的报告,并表明:(1)右前额叶θ活动是一种支持言语和肢体抑制的amodal振荡机制;(2)在阴极刺激后,言语前额叶电极的θ活动比肢体前额叶电极的θ活动更大,这可能反映出与肢体运动相比,言语等更复杂的运动任务分配了更多的神经资源。这些发现对帕金森病等语言和肢体运动均受损的疾病具有转化意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Theta oscillations within right dorsolateral prefrontal cortex contribute differently to speech versus limb inhibition

Theta oscillations within right dorsolateral prefrontal cortex contribute differently to speech versus limb inhibition

Evidence suggests that speech and limb movement inhibition are subserved by common neural mechanisms, particularly within the right prefrontal cortex. In a recent study, we found that cathodal stimulation of right dorsolateral prefrontal cortex (rDLPFC) differentially modulated P3 event-related potentials for speech versus limb inhibition. In the present study, we further analyzed these data to examine the effects of cathodal high-definition transcranial direct current stimulation (HD-tDCS) over rDLPFC on frontal theta - an oscillatory marker of cognitive control - in response to speech and limb inhibition, during a Go/No-Go task in 21 neurotypical adults. Electroencephalography data demonstrated that both speech and limb No-Go elicited prominent theta activity over right prefrontal electrodes, with stronger activity for speech compared to limb. Moreover, we found that cathodal stimulation significantly increased theta power over right prefrontal electrodes for speech versus limb No-Go. Source analysis revealed that cathodal, but not sham, stimulation increased theta activity within rDLPFC and bilateral premotor cortex for speech No-Go compared to limb movement inhibition. These findings complement our previous report and suggest (1) right prefrontal theta activity is an amodal oscillatory mechanism supporting speech and limb inhibition, (2) larger theta activity in prefrontal electrodes for speech versus limb following cathodal stimulation may reflect allocation of additional neural resources for a more complex motor task, such as speech compared to limb movement. These findings have translational implications for conditions such as Parkinson's disease, wherein both speech and limb movement are impaired.

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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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