设计壳聚糖-透明质酸纳米载体的有效策略:从合成到药物输送再到化疗。

Long-Quy Hong, Thao N T Ho, Son T Cu, Lien Tuyet Ngan, Tran Ngoc Quyen, Tien T Dang
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引用次数: 0

摘要

由于癌症对人类健康造成的巨大负担,生物医学领域在开发更有效的抗癌药物方面面临着持续的挑战。由于天然多糖具有生物相容性、生物可降解性、非免疫原性和无毒性等特性,人们对其在纳米药物中的应用进行了广泛的研究。这些特性使它们成为治疗癌症的有效给药系统。壳聚糖透明质酸纳米颗粒(CSHANp)系统由壳聚糖和透明质酸纳米颗粒组成,在作为各种癌症药物的纳米载体方面表现出相当大的潜力,是目前最理想的系统之一。CSHANps 具有出色的载药能力、对药物释放的精确控制以及对癌细胞的特殊选择性。这些特性增强了对癌细胞的治疗效果。本文旨在全面分析 CSHANp,重点介绍其特点、生产技术、应用和未来前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effective Strategies in Designing Chitosan-hyaluronic Acid Nanocarriers: From Synthesis to Drug Delivery Towards Chemotherapy.

The biomedical field faces an ongoing challenge in developing more effective anti-cancer medication due to the significant burden that cancer poses on human health. Extensive research has been conducted on the utilization of natural polysaccharides in nanomedicine owing to their properties of biocompatibility, biodegradability, non-immunogenicity, and non-toxicity. These characteristics make them a potent drug delivery system for cancer therapy. The chitosan hyaluronic acid nanoparticle (CSHANp) system, consisting of chitosan and hyaluronic acid nanoparticles, has exhibited considerable potential as a nanocarrier for various cancer drugs, rendering it one of the most auspicious systems presently accessible. The CSHANps demonstrate remarkable drug loading capacity, precise control over drug release, and exceptional selectivity towards cancer cells. These properties enhance the therapeutic effectiveness against cancerous cells. This article aims to provide a comprehensive analysis of CSHANp, focusing on its characteristics, production techniques, applications, and future prospects.

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