从低剂量超高分辨率 CT 导出的四肢放射影像:一项模型研究。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-11-01 Epub Date: 2024-02-03 DOI:10.1007/s00256-024-04600-y
Andrew M Hernandez, Christopher O Bayne, Cyrus Bateni, Ramit Lamba, John M Boone
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引用次数: 0

摘要

目的证明低剂量超高分辨率 CT(UHRCT)图像在四肢模型上生成高质量放射图像的潜力,并估算为此所需的辐射剂量:在 UHRCT 扫描仪上使用高分辨率四肢协议,以全剂量、半剂量和四分之一剂量水平对包含真实人体骨骼的手部和膝部模型进行成像。原始数据采用滤波背投影(FBP)和迭代重建算法(AIDR3D)进行重建。使用定制软件,将每个 CT 容积数据集转换为衰减系数,然后将点源的容积数据集正向投影到二维合成探测器上,生成合成放射图像(synDX)。测量了所有剂量水平的合成放射图像的信噪比(SNR),并以 FD 合成放射图像为参照计算了均方根误差(RMSE):结果:建议的工作流程可在任意角度生成高质量的同步数据交换。对于 FBP,膝关节和手部模型的信噪比与辐射剂量水平基本一致。对于膝关节模型,迭代重建的信噪比比 FBP 高 6.1%。最低剂量水平的 RMSE 值总体较高,并随着剂量的增加而单调降低。在模型骨骼细节的可视化方面,没有观察到实质性的差异:结论:UHRCT 采集的四肢图像细节细腻,有助于生成高质量的射线照片,可能无需在传统的数字射线摄影系统上进行额外的扫描。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extremity radiographs derived from low-dose ultra-high-resolution CT: a phantom study.

Objective: To demonstrate the potential of low-dose ultra-high-resolution CT (UHRCT) images to generate high-quality radiographic images on extremity phantoms and to estimate the radiation dose required for this.

Materials and methods: A hand and knee phantom containing real human bones was imaged on an UHRCT scanner at full-dose, half-dose, and quarter-dose levels using a high-resolution extremity protocol. The raw data was reconstructed using both filtered back projection (FBP) and an iterative reconstruction algorithm (AIDR3D). Using custom designed software, each CT volume data set was converted to attenuation coefficients, and then a synthesized radiograph (synDX) was generated by forward projecting the volume data sets from a point source onto a 2D synthetic detector. The signal-to-noise ratio (SNR) was measured in the synDXs across all dose levels and the root-mean-squared error (RMSE) was computed with the FD synDXs as the reference.

Results: The proposed workflow generates high-quality synDXs at any arbitrary angle. For FBP, the SNR largely tracked with the radiation dose levels for both the knee and hand phantoms. For the knee phantom, iterative reconstruction provided a 6.1% higher SNR when compared to FBP. The RMSE was overall higher for the lowest dose levels and monotonically decreased with increasing dose. No substantial differences were observed qualitatively in the visualization of skeletal detail of the phantoms.

Conclusion: The fine detail provided by UHRCT acquisitions of extremities facilitates the ability to generate quality radiographs, potentially eliminating the need for additional scanning on a conventional digital radiography system.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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