伴纤维瘤基质的肾细胞癌中的复发性 MTOR 突变：2 例肿瘤的报告

IF 0.9 4区医学 Q4 PATHOLOGY

International Journal of Surgical Pathology Pub Date : 2024-10-01 Epub Date: 2024-02-04 DOI:10.1177/10668969241228295

Ejas Palathingal Bava, Nilesh Gupta, Fatimah I Alruwaii, Ryan Nelson, Khaleel I Al-Obaidy

{"title":"伴纤维瘤基质的肾细胞癌中的复发性 MTOR 突变：2 例肿瘤的报告","authors":"Ejas Palathingal Bava, Nilesh Gupta, Fatimah I Alruwaii, Ryan Nelson, Khaleel I Al-Obaidy","doi":"10.1177/10668969241228295","DOIUrl":null,"url":null,"abstract":"Renal cell carcinoma with fibromyomatous stroma, recognized as a provisional entity in the current 2022 World Health Organization classification of renal neoplasms, is rare. Recent evidence suggests recurrent alterations in the mTOR pathway, supporting its recognition as a distinct entity. Herein, we report 2 renal cell carcinomas with fibromyomatous stroma with MTOR mutations occurring in 62- and 72-year-old women and review the literature to support its recognition as a distinct entity, focusing on the characteristic morphology, immunohistochemical staining patterns as well as genetic alterations.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recurrent MTOR Mutations in Renal Cell Carcinoma With Fibromyomatous Stroma: A Report of 2 Tumors.\",\"authors\":\"Ejas Palathingal Bava, Nilesh Gupta, Fatimah I Alruwaii, Ryan Nelson, Khaleel I Al-Obaidy\",\"doi\":\"10.1177/10668969241228295\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Renal cell carcinoma with fibromyomatous stroma, recognized as a provisional entity in the current 2022 World Health Organization classification of renal neoplasms, is rare. Recent evidence suggests recurrent alterations in the mTOR pathway, supporting its recognition as a distinct entity. Herein, we report 2 renal cell carcinomas with fibromyomatous stroma with MTOR mutations occurring in 62- and 72-year-old women and review the literature to support its recognition as a distinct entity, focusing on the characteristic morphology, immunohistochemical staining patterns as well as genetic alterations.\",\"PeriodicalId\":14416,\"journal\":{\"name\":\"International Journal of Surgical Pathology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Surgical Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/10668969241228295\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/2/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Surgical Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10668969241228295","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/4 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

在世界卫生组织现行的 2022 年肾脏肿瘤分类中，带有纤维肌瘤基质的肾细胞癌被认定为一个临时实体，但这种肾细胞癌并不多见。最近的证据表明，mTOR通路反复发生改变，支持将其认定为一个独特的实体。在此，我们报告了发生在62岁和72岁女性身上的2例伴有MTOR突变的纤维肌瘤性基质的肾细胞癌，并回顾了相关文献，以支持将其认定为一个独特的实体，重点关注其特征性形态、免疫组化染色模式以及基因改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Recurrent MTOR Mutations in Renal Cell Carcinoma With Fibromyomatous Stroma: A Report of 2 Tumors.

Renal cell carcinoma with fibromyomatous stroma, recognized as a provisional entity in the current 2022 World Health Organization classification of renal neoplasms, is rare. Recent evidence suggests recurrent alterations in the mTOR pathway, supporting its recognition as a distinct entity. Herein, we report 2 renal cell carcinomas with fibromyomatous stroma with MTOR mutations occurring in 62- and 72-year-old women and review the literature to support its recognition as a distinct entity, focusing on the characteristic morphology, immunohistochemical staining patterns as well as genetic alterations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Surgical Pathology 医学-病理学

CiteScore

2.10

自引率

0.00%

发文量

198

审稿时长

1 months

期刊介绍： International Journal of Surgical Pathology (IJSP) is a peer-reviewed journal published eight times a year, which offers original research and observations covering all major organ systems, timely reviews of new techniques and procedures, discussions of controversies in surgical pathology, case reports, and images in pathology. This journal is a member of the Committee on Publication Ethics (COPE).