ST 段抬高型心肌梗死(STEMI)患者的内皮一氧化氮合酶(eNOS)基因多态性(Glu298asp)和一氧化氮(NO)水平。

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Mohit Dayal Gupta , Cherian Akkarappatty , Shekhar Kunal , Girish MP , Ankit Bansal , Vishal Batra , Sanjay Tyagi
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引用次数: 0

摘要

背景:内皮一氧化氮合成酶(eNOS)的基因多态性与多种心血管疾病(CVDs)的发生有关:这项研究包括 300 名年轻的 ST 段抬高型心肌梗死(STEMI)患者和 300 名健康对照者。STEMI 患者被分为两组:早发冠状动脉疾病(CAD)(STEMI40 岁)和健康对照组(STEMI50 岁)。对受试者和对照组 eNOS 基因(894G/T)的遗传多态性进行了评估。对患者和对照组的血浆一氧化氮(NO)水平进行了估计:研究对象的平均年龄为(49.7 ± 9.2)岁,其中 58 例(19.3%)患者患有早发性冠状动脉综合征。STEMI患者和健康对照组之间在基因型(P = 0.589,几率比(OR)= 0.9,95 % CI = 0.6-1.6)和等位基因水平(P = 0.173,OR = 1.2,95 % CI = 0.9-1.4)上无明显差异。在年龄大于 40 岁的 STEMI 患者中,基因型 894 TT 的频率明显更高(P = 0.047,OR:2.5;95 % CI = 1.0-6.0)。早发型 CAD(STEMI 年龄为 40 岁(P = 0.001))与等位基因水平(P = 0.493)之间无明显差异:结论:eNOS 基因多态性 Glu298Asp 与年龄大于 40 岁的 STEMI 患者有明显关联。结论:eNOS 基因多态性 Glu298Asp 与年龄大于 40 岁的 STEMI 患者有明显相关性,但在早发型 CAD 患者中未观察到这种关联。年龄大于 40 岁的 STEMI 患者体内 NO 水平较低,这表明 NO 有可能成为心血管疾病的标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298asp) and nitric oxide (NO) levels in patients with ST-segment elevation myocardial infarction (STEMI)

Background

Genetic polymorphism in endothelial Nitric Oxide Synthase (eNOS) are associated with occurrence of multiple cardiovascular diseases (CVDs).

Methods

This study included 300 young ST-segment elevation myocardial infarction (STEMI) patients and 300 healthy controls. STEMI patients were divided into two groups: premature coronary artery disease [CAD] (STEMI<40 years of age) and older STEMI (>40 years of age). Genetic polymorphisms in the eNOS gene (894G/T) was evaluated in both subjects and controls. Plasma levels of nitric oxide (NO) were estimated for both patients as well as controls.

Results

Mean age of the study population was 49.7 ± 9.2 years with premature CAD being present in 58 (19.3 %) patients. No significant difference at genotypic (P = 0.589, odds ratio (OR) = 0.9, 95 % CI = 0.6–1.6) and allelic level (P = 0.173, OR = 1.2, 95 % CI = 0.9–1.4) was observed between STEMI patients and healthy controls. Genotype 894 TT had significantly higher frequency in STEMI patients >40 years (P = 0.047, OR: 2.5; 95 % CI = 1.0–6.0). No significant difference at genotypic (P = 0.279) and allelic level (P = 0.493) was observed between premature CAD (STEMI age <40 years) and healthy controls. NO levels (131 ± 59.6 μM vs 118.11 ± 49.96 μM; P = 0.001) was significantly higher in healthy controls as compared to STEMI patients >40 years of age (P= 0.001).

Conclusion

There was significant association of eNOS gene polymorphism Glu298Asp with STEMI patients > 40 years. However, this association was not observed in premature CAD patients. Lower levels of NO in STEMI patients >40 years suggests its potential role as a marker of CVD.

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来源期刊
Indian heart journal
Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.60
自引率
6.70%
发文量
82
审稿时长
52 days
期刊介绍: Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.
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