睡眠是否能促进对急性压力的适应:一项实验研究

IF 4.3 2区 医学 Q1 NEUROSCIENCES
Emil Hein , Risto Halonen , Thomas Wolbers , Tommi Makkonen , Markus Kyllönen , Liisa Kuula , Ilmari Kurki , Philipp Stepnicka , Anu-Katriina Pesonen
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引用次数: 0

摘要

目的有大量证据表明慢性压力对睡眠有影响,但以急性压力为重点的实验性睡眠研究却很少,而且结果也不尽相同。我们的研究旨在通过多导睡眠图(PSG)的测量,实验性地研究睡前社会压力对随后一夜睡眠动态的影响,从而填补这一空白。方法34名健康人(65%为女性,年龄:25.76岁,平均年龄:3.35岁)在虚拟现实(VR)中接受了压力诱导(SC)或中性控制条件(CC)。我们使用通宵脑电图测量来分析各睡眠周期的睡眠结构和功率谱密度(PSD),并测量了心率及其变异性(HRV)、皮肤电活动(EDA)和唾液皮质醇,以捕捉 VR 任务期间和睡眠前的生理唤醒。在SC中,整夜N2和SWS阶段的β-低(16-24Hz)和β-高(25-35Hz)频率范围内的PSD都升高了。结论在随后的睡眠期,尤其是在早期睡眠中,睡眠通过延长SWS的持续时间促进了对急性社会压力的适应。类似的恢复性睡眠平衡效应在动物应激模型研究中得到了充分证实,但在人类实验研究中却未见报道。N2和SWS阶段的高频PSD活动是否也能起到缓解瞬时压力的作用,目前尚无定论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does sleep promote adaptation to acute stress: An experimental study

Objectives

Evidence of the impact of chronic stress on sleep is abundant, yet experimental sleep studies with a focus on acute stress are scarce and the results are mixed. Our study aimed to fill this gap by experimentally investigating the effects of pre-sleep social stress on sleep dynamics during the subsequent night, as measured with polysomnography (PSG).

Methods

Thirty-four healthy individuals (65% females, Mage = 25.76 years SD = 3.35) underwent a stress-inducing (SC) or neutral control condition (CC) in virtual reality (VR). We used overnight EEG measurements to analyze the basic sleep parameters and power spectral density (PSD) across the sleep cycles, and measured heart rate and its variability (HRV), skin electrodermal activity (EDA), and salivary cortisol to capture physiological arousal during the VR task and the pre-sleep period.

Results

Following acute stress (SC), the amount of slow-wave sleep (SWS) was higher and N2 sleep lower relative to CC, specifically in the first sleep cycle. In SC, PSD was elevated in the beta-low (16–24 Hz) and beta-high (25–35 Hz) frequency ranges during both stages N2 and SWS over the entire night.

Conclusions

Sleep promoted adaptation to acute social stress by a longer duration of SWS in the subsequent sleep period, especially in early sleep. A similar homeostatic effect towards restorative sleep is well-evidenced in animal model stress studies but has not been previously reported in experimental human studies. Whether the high-frequency PSD activity during stages N2 and SWS also serves in the resolution of transient stress, remains open.

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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
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