不是卡芬太尼--一个意外检测到 Xylazine 的案例。

IF 1.8 Q3 MEDICAL LABORATORY TECHNOLOGY
Jasper X Zheng, Shelby Randall, Kristin Grimsrud, Scott Bainbridge, Nam K Tran
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引用次数: 0

摘要

数十年来,恶嗪一直被兽医学用作麻醉和镇痛镇静剂,以促进大型动物的安全处理、诊断检测和外科手术。目前,异丙嗪正在对人类健康构成威胁。在非法药物供应链中发现了它,通常是作为一种掺杂物。更常见的情况是,制药商将其添加到非法药物(最著名的是芬太尼)中,以增强药物效果。最终用户往往不知道它的存在。这一点令人震惊,因为在实验室检测不充分和缺乏逆转剂的情况下,却有大量因服用过量过量使用异丙嗪而死亡的案例。在本文中,我们介绍了加利福尼亚大学戴维斯分校健康中心通过气相色谱-串联质谱法发现的第一例异丙嗪病例,尽管该病例的临床表现非常轻微。我们希望提高人们对这种在评估中经常被忽略的潜在致命掺假剂的认识,并为研究这一持续存在的问题提供更多机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Not Carfentanil-A Case of Unexpected Xylazine Detection.

Historically, xylazine has been utilized in veterinary medicine for decades as an anesthetic and analgesic sedative to facilitate safe handling, diagnostic testing, and surgical procedures in large animals. Currently, xylazine is an emerging threat to human health. It has been detected in the illicit drug supply chain, often as an adulterant. It has been more commonly added to illicit substances, most notably fentanyl, by drugmakers to enhance drug effect. End users are often unaware of its presence. This is alarming given the large number of xylazine-involved overdose deaths while laboratory detections are deficient and reversal agents are absent. Herein, we present the first documented case of xylazine identified via gas chromatography-tandem mass spectrometry at University of California Davis Health despite a peculiarly mild clinical presentation. We hope to increase awareness of this potentially fatal adulterant that is often missed in evaluation and engender further opportunities to study this ongoing issue.

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来源期刊
Journal of Applied Laboratory Medicine
Journal of Applied Laboratory Medicine MEDICAL LABORATORY TECHNOLOGY-
CiteScore
3.70
自引率
5.00%
发文量
137
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