与芍药相关的内生毛癣菌产生的两种新的堇菜类倍半萜化合物

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-07-03 DOI:10.1080/14786419.2024.2308001

Yun-Peng Sun , Man-Li Zhang , Yang Yu , Ran Sun , Si-Rui Wang , Jin-Song Liu , Guo-Kai Wang

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引用次数: 0

摘要

从与药用植物芍药（Paeonia lactiflora Pall）相关的内生毛癣菌中分离出了两种新的堇菜烷类倍半萜化合物，即 harzianes A 和 B（1 和 2），以及两种已知的环戊二醇类倍半萜化合物（3-4）和四种已知的甾醇（5-8）。通过光谱分析（HR-ESI-MS、1D 和 2D NMR）确定了化合物 1 和 2 是一对各向异性异构体，并通过 ECD 计算确定了它们的绝对构型。对所有化合物都进行了抗炎活性测试，但没有一个化合物显示出这种活性。

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Two new acorane-type sesquiterpenoids from an endophytic Trichoderma harzianum associated with Paeonia lactiflora Pall

Two new acorane-type sesquiterpenoids, harzianes A and B (1 and 2), together with two known cyclonerodiol-type sesquiterpenoids (3–4) and four known sterols (5–8) were isolated from the endophytic Trichoderma harzianum, associated with the medicinal plant Paeonia lactiflora Pall. Compounds 1 and 2 were identified as a pair of heterotropic isomers by spectroscopic analysis (HR-ESI-MS, 1D and 2D NMR), and their absolute configurations were determined by ECD calculations. All compounds were tested for anti-inflammatory activity, however, none demonstrated such activity.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.