铁前列素-1能改善脂肪肝肝移植大鼠的预后并调节其肠道微生物群。

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-02 DOI:10.2217/fmb-2023-0133

Mengshu Yuan, Yuxin Wang, Xiaorong Tian, Weiping Zheng, Huaiwen Zuo, Xinru Zhang, Hongli Song

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引用次数: 0

摘要

目的：研究铁前列素-1（Fer-1）对改善脂肪肝肝移植受者预后和调节大鼠肠道微生物群的影响。研究方法我们获得了脂肪肝移植物并建立了肝移植模型。受者分为假组、肝移植组和 Fer-1 治疗组，分别在术后 1 天和 7 天进行评估（n = 6）。结果与结论Fer-1能促进脂肪肝移植物和肠道组织学结构和功能的恢复，改善肝移植后受者的炎症反应。Fer-1 可减少肠道微生物群的致病性，降低受体对铁的吸收，改善脂肪代谢，从而保护脂肪肝移植物。

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Ferrostatin-1 improves prognosis and regulates gut microbiota of steatotic liver transplantation recipients in rats.

Aims: To investigate the effects of Ferrostatin-1 (Fer-1) on improving the prognosis of liver transplant recipients with steatotic liver grafts and regulating gut microbiota in rats. Methods: We obtained steatotic liver grafts and established a liver transplantation model. Recipients were divided into sham, liver transplantation and Fer-1 treatment groups, which were assessed 1 and 7 days after surgery (n = 6). Results & conclusion: Fer-1 promotes recovery of the histological structure and function of steatotic liver grafts and the intestinal tract, and improves inflammatory responses of recipients following liver transplantation. Fer-1 reduces gut microbiota pathogenicity, and lowers iron absorption and improves fat metabolism of recipients, thereby protecting steatotic liver grafts.

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.