渴望控制:恶性疟原虫染色质的代谢物信号传递

IF 5.9 2区 生物学 Q1 MICROBIOLOGY
Ruth Lappalainen, Manish Kumar, Manoj T Duraisingh
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引用次数: 0

摘要

人类疟原虫恶性疟原虫在哺乳动物和蚊子这两种宿主体内经历了复杂的生命周期,不断受到环境营养变化的影响。表观遗传机制控制着转录开关,对寄生虫的存活和增殖至关重要。感染红细胞的寄生虫对多种营养物质具有辅助营养作用,越来越多的证据表明,各种代谢物是表观遗传修饰的直接底物,它们的丰度与寄生虫基因表达的变化直接相关。在此,我们回顾了对改变组蛋白密码的代谢变化导致疟原虫转录程序变化的最新认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hungry for control: metabolite signaling to chromatin in Plasmodium falciparum

The human malaria parasite Plasmodium falciparum undergoes a complex life cycle in two hosts, mammalian and mosquito, where it is constantly subjected to environmental changes in nutrients. Epigenetic mechanisms govern transcriptional switches and are essential for parasite persistence and proliferation. Parasites infecting red blood cells are auxotrophic for several nutrients, and mounting evidence suggests that various metabolites act as direct substrates for epigenetic modifications, with their abundance directly relating to changes in parasite gene expression. Here, we review the latest understanding of metabolic changes that alter the histone code resulting in changes to transcriptional programmes in malaria parasites.

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来源期刊
Current opinion in microbiology
Current opinion in microbiology 生物-微生物学
CiteScore
10.00
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Host-microbe interactions: bacteria Cell regulation Environmental microbiology Host-microbe interactions: fungi/parasites/viruses Antimicrobials Microbial systems biology Growth and development: eukaryotes/prokaryotes
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