Md. Kaisar Rahman, Howard Rodriguez-Mori, Guy H. Loneragan, Babafela Awosile
{"title":"2002 年至 2021 年美国食用动物、零售肉类和人类监测计划中细菌的β-内酰胺酶基因","authors":"Md. Kaisar Rahman, Howard Rodriguez-Mori, Guy H. Loneragan, Babafela Awosile","doi":"10.1016/j.cimid.2024.102139","DOIUrl":null,"url":null,"abstract":"<div><p>The spread of beta-lactamase-producing bacteria is a global public-health concern. This study aimed to explore the distribution of beta-lactamases reported in three sampling sources (cecal, retail meat, and human) collected as part of integrated surveillance in the United States. We retrieved and analyzed data from the United States National Antimicrobial Resistance Monitoring Systems (NARMS) from 2002 to 2021. A total of 115 beta-lactamase genes were detected in <em>E. coli</em>, <em>Salmonella enterica</em>, <em>Campylobacter</em>, <em>Shigella</em> and <em>Vibrio</em>: including 35 genes from cecal isolates, 32 genes from the retail meat isolates, and 104 genes from the human isolates. Three genes in <em>E. coli</em> (<em>bla</em><sub>CMY-2,</sub> <em>bla</em><sub>TEM-1A</sub>, and <em>bla</em><sub>TEM-1B</sub>), 6 genes in Salmonella enterica (<em>bla</em><sub>CARB-2</sub>, <em>bla</em><sub>CMY-2</sub>, <em>bla</em><sub>CTXM-65</sub>, <em>bla</em><sub>TEM-1A</sub>, <em>bla</em><sub>TEM-1B</sub>, and <em>bla</em><sub>HERA-3</sub>), and 2 genes in <em>Campylobacter</em> spp. (<em>bla</em><sub>OXA-61</sub> and <em>bla</em><sub>OXA-449</sub>) have been detected across food animals (cattle, chicken, swine, and turkey) and humans over the study period. <em>bla</em><sub>CTXM-55</sub> has been detected in <em>E. coli</em> isolates from the four food animal sources while <em>bla</em><sub>CTXM-15</sub> and <em>bla</em><sub>CTXM-27</sub> were found only in cattle and swine. In <em>Salmonella enterica</em>, <em>bla</em><sub>CTXM-2</sub>, <em>bla</em><sub>CTXM-9</sub>, <em>bla</em><sub>CTXM-14</sub>, <em>bla</em><sub>CTXM-15</sub>, <em>bla</em><sub>CTXM-27</sub>, <em>bla</em><sub>CTXM-55</sub>, and <em>bla</em><sub>NDM-1</sub> were only detected among human isolates. <em>bla</em><sub>OXAs</sub> and <em>bla</em><sub>CARB</sub> were bacteria-specific and the only beta-lactamase genes detected in <em>Campylobacter</em> spp. and <em>Vibrio</em> spp respectively. The proportions of beta-lactamase genes detected varies from bacteria to bacteria. This study provided insights on the beta-lactamase genes detected in bacteria in food animals and humans in the United States. This is necessary for better understanding the molecular epidemiology of clinically important beta-lactamases in one health interface.</p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"106 ","pages":"Article 102139"},"PeriodicalIF":2.0000,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Beta-lactamase genes in bacteria from food animals, retail meat, and human surveillance programs in the United States from 2002 to 2021\",\"authors\":\"Md. Kaisar Rahman, Howard Rodriguez-Mori, Guy H. Loneragan, Babafela Awosile\",\"doi\":\"10.1016/j.cimid.2024.102139\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The spread of beta-lactamase-producing bacteria is a global public-health concern. This study aimed to explore the distribution of beta-lactamases reported in three sampling sources (cecal, retail meat, and human) collected as part of integrated surveillance in the United States. We retrieved and analyzed data from the United States National Antimicrobial Resistance Monitoring Systems (NARMS) from 2002 to 2021. A total of 115 beta-lactamase genes were detected in <em>E. coli</em>, <em>Salmonella enterica</em>, <em>Campylobacter</em>, <em>Shigella</em> and <em>Vibrio</em>: including 35 genes from cecal isolates, 32 genes from the retail meat isolates, and 104 genes from the human isolates. Three genes in <em>E. coli</em> (<em>bla</em><sub>CMY-2,</sub> <em>bla</em><sub>TEM-1A</sub>, and <em>bla</em><sub>TEM-1B</sub>), 6 genes in Salmonella enterica (<em>bla</em><sub>CARB-2</sub>, <em>bla</em><sub>CMY-2</sub>, <em>bla</em><sub>CTXM-65</sub>, <em>bla</em><sub>TEM-1A</sub>, <em>bla</em><sub>TEM-1B</sub>, and <em>bla</em><sub>HERA-3</sub>), and 2 genes in <em>Campylobacter</em> spp. (<em>bla</em><sub>OXA-61</sub> and <em>bla</em><sub>OXA-449</sub>) have been detected across food animals (cattle, chicken, swine, and turkey) and humans over the study period. <em>bla</em><sub>CTXM-55</sub> has been detected in <em>E. coli</em> isolates from the four food animal sources while <em>bla</em><sub>CTXM-15</sub> and <em>bla</em><sub>CTXM-27</sub> were found only in cattle and swine. In <em>Salmonella enterica</em>, <em>bla</em><sub>CTXM-2</sub>, <em>bla</em><sub>CTXM-9</sub>, <em>bla</em><sub>CTXM-14</sub>, <em>bla</em><sub>CTXM-15</sub>, <em>bla</em><sub>CTXM-27</sub>, <em>bla</em><sub>CTXM-55</sub>, and <em>bla</em><sub>NDM-1</sub> were only detected among human isolates. <em>bla</em><sub>OXAs</sub> and <em>bla</em><sub>CARB</sub> were bacteria-specific and the only beta-lactamase genes detected in <em>Campylobacter</em> spp. and <em>Vibrio</em> spp respectively. The proportions of beta-lactamase genes detected varies from bacteria to bacteria. This study provided insights on the beta-lactamase genes detected in bacteria in food animals and humans in the United States. This is necessary for better understanding the molecular epidemiology of clinically important beta-lactamases in one health interface.</p></div>\",\"PeriodicalId\":50999,\"journal\":{\"name\":\"Comparative Immunology Microbiology and Infectious Diseases\",\"volume\":\"106 \",\"pages\":\"Article 102139\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative Immunology Microbiology and Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S014795712400016X\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative Immunology Microbiology and Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S014795712400016X","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Beta-lactamase genes in bacteria from food animals, retail meat, and human surveillance programs in the United States from 2002 to 2021
The spread of beta-lactamase-producing bacteria is a global public-health concern. This study aimed to explore the distribution of beta-lactamases reported in three sampling sources (cecal, retail meat, and human) collected as part of integrated surveillance in the United States. We retrieved and analyzed data from the United States National Antimicrobial Resistance Monitoring Systems (NARMS) from 2002 to 2021. A total of 115 beta-lactamase genes were detected in E. coli, Salmonella enterica, Campylobacter, Shigella and Vibrio: including 35 genes from cecal isolates, 32 genes from the retail meat isolates, and 104 genes from the human isolates. Three genes in E. coli (blaCMY-2,blaTEM-1A, and blaTEM-1B), 6 genes in Salmonella enterica (blaCARB-2, blaCMY-2, blaCTXM-65, blaTEM-1A, blaTEM-1B, and blaHERA-3), and 2 genes in Campylobacter spp. (blaOXA-61 and blaOXA-449) have been detected across food animals (cattle, chicken, swine, and turkey) and humans over the study period. blaCTXM-55 has been detected in E. coli isolates from the four food animal sources while blaCTXM-15 and blaCTXM-27 were found only in cattle and swine. In Salmonella enterica, blaCTXM-2, blaCTXM-9, blaCTXM-14, blaCTXM-15, blaCTXM-27, blaCTXM-55, and blaNDM-1 were only detected among human isolates. blaOXAs and blaCARB were bacteria-specific and the only beta-lactamase genes detected in Campylobacter spp. and Vibrio spp respectively. The proportions of beta-lactamase genes detected varies from bacteria to bacteria. This study provided insights on the beta-lactamase genes detected in bacteria in food animals and humans in the United States. This is necessary for better understanding the molecular epidemiology of clinically important beta-lactamases in one health interface.
期刊介绍:
Comparative Immunology, Microbiology & Infectious Diseases aims to respond to the concept of "One Medicine" and to provide a venue for scientific exchange. Based on the concept of "Comparative Medicine" interdisciplinary cooperation between specialists in human and animal medicine is of mutual interest and benefit. Therefore, there is need to combine the respective interest of physicians, veterinarians and other health professionals for comparative studies relevant to either human or animal medicine .
The journal is open to subjects of common interest related to the immunology, immunopathology, microbiology, parasitology and epidemiology of human and animal infectious diseases, especially zoonotic infections, and animal models of human infectious diseases. The role of environmental factors in disease emergence is emphasized. CIMID is mainly focusing on applied veterinary and human medicine rather than on fundamental experimental research.