2002 年至 2021 年美国食用动物、零售肉类和人类监测计划中细菌的β-内酰胺酶基因

IF 2 3区 农林科学 Q4 IMMUNOLOGY
Md. Kaisar Rahman, Howard Rodriguez-Mori, Guy H. Loneragan, Babafela Awosile
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引用次数: 0

摘要

产β-内酰胺酶细菌的传播是一个全球性的公共卫生问题。本研究旨在探索作为美国综合监测一部分的三个采样来源(盲肠、零售肉类和人体)中报告的 beta-内酰胺酶的分布情况。我们从美国国家抗菌药耐药性监测系统(NARMS)中检索并分析了 2002 年至 2021 年的数据。在大肠杆菌、肠炎沙门氏菌、弯曲杆菌、志贺氏菌和弧菌中总共检测到 115 个 beta-内酰胺酶基因:其中 35 个基因来自盲肠分离物,32 个基因来自零售肉类分离物,104 个基因来自人类分离物。大肠杆菌中有 3 个基因(blaCMY-2、blaTEM-1A 和 blaTEM-1B),肠炎沙门氏菌中有 6 个基因(blaCARB-2、blaCMY-2、blaCTXM-65、blaTEM-1A、blaTEM-1B 和 blaHERA-3),弯曲杆菌属中有 2 个基因(blaOXA-61)。(在研究期间,在食用动物(牛、鸡、猪和火鸡)和人类中都检测到了 blaCTXM-55,而 blaCTXM-15 和 blaCTXM-27 只在牛和猪中发现。在肠炎沙门氏菌中,只在人类分离物中检测到 blaCTXM-2、blaCTXM-9、blaCTXM-14、blaCTXM-15、blaCTXM-27、blaCTXM-55 和 blaNDM-1。blaOXAs 和 blaCARB 是细菌特异性基因,分别是弯曲杆菌属和弧菌属中唯一检测到的β-内酰胺酶基因。检测到的β-内酰胺酶基因比例因细菌而异。这项研究有助于深入了解美国食用动物和人类细菌中检测到的β-内酰胺酶基因。这对于更好地了解临床上重要的β-内酰胺酶在一个健康界面中的分子流行病学十分必要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beta-lactamase genes in bacteria from food animals, retail meat, and human surveillance programs in the United States from 2002 to 2021

The spread of beta-lactamase-producing bacteria is a global public-health concern. This study aimed to explore the distribution of beta-lactamases reported in three sampling sources (cecal, retail meat, and human) collected as part of integrated surveillance in the United States. We retrieved and analyzed data from the United States National Antimicrobial Resistance Monitoring Systems (NARMS) from 2002 to 2021. A total of 115 beta-lactamase genes were detected in E. coli, Salmonella enterica, Campylobacter, Shigella and Vibrio: including 35 genes from cecal isolates, 32 genes from the retail meat isolates, and 104 genes from the human isolates. Three genes in E. coli (blaCMY-2, blaTEM-1A, and blaTEM-1B), 6 genes in Salmonella enterica (blaCARB-2, blaCMY-2, blaCTXM-65, blaTEM-1A, blaTEM-1B, and blaHERA-3), and 2 genes in Campylobacter spp. (blaOXA-61 and blaOXA-449) have been detected across food animals (cattle, chicken, swine, and turkey) and humans over the study period. blaCTXM-55 has been detected in E. coli isolates from the four food animal sources while blaCTXM-15 and blaCTXM-27 were found only in cattle and swine. In Salmonella enterica, blaCTXM-2, blaCTXM-9, blaCTXM-14, blaCTXM-15, blaCTXM-27, blaCTXM-55, and blaNDM-1 were only detected among human isolates. blaOXAs and blaCARB were bacteria-specific and the only beta-lactamase genes detected in Campylobacter spp. and Vibrio spp respectively. The proportions of beta-lactamase genes detected varies from bacteria to bacteria. This study provided insights on the beta-lactamase genes detected in bacteria in food animals and humans in the United States. This is necessary for better understanding the molecular epidemiology of clinically important beta-lactamases in one health interface.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
102
审稿时长
40 days
期刊介绍: Comparative Immunology, Microbiology & Infectious Diseases aims to respond to the concept of "One Medicine" and to provide a venue for scientific exchange. Based on the concept of "Comparative Medicine" interdisciplinary cooperation between specialists in human and animal medicine is of mutual interest and benefit. Therefore, there is need to combine the respective interest of physicians, veterinarians and other health professionals for comparative studies relevant to either human or animal medicine . The journal is open to subjects of common interest related to the immunology, immunopathology, microbiology, parasitology and epidemiology of human and animal infectious diseases, especially zoonotic infections, and animal models of human infectious diseases. The role of environmental factors in disease emergence is emphasized. CIMID is mainly focusing on applied veterinary and human medicine rather than on fundamental experimental research.
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