活动性癌症患者的静脉血栓栓塞管理。

IF 3.4 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Cleveland Clinic Journal of Medicine Pub Date : 2024-02-02 DOI:10.3949/ccjm.91a.23017

Heloni M Dave, Alok A Khorana

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引用次数: 0

摘要

静脉血栓栓塞症（VTE）是癌症患者的主要健康负担，会导致发病、急诊就诊、住院和死亡。治疗具有挑战性，因为必须平衡抗凝剂带来的血栓复发和出血风险。治疗模式正在从低分子量肝素单一疗法转变。最近的多项随机对照试验已经证明了直接口服抗凝剂在这种情况下的安全性和有效性。目前的研究正在评估因子 XI 抑制剂作为治疗癌症相关 VTE 的潜在疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Management of venous thromboembolism in patients with active cancer.

Venous thromboembolism (VTE) is a major health burden in patients with cancer, causing morbidity, emergency room visits, hospitalizations, and death. Treatment is challenging, as it is necessary to balance the risk of recurrent thrombosis and bleeding associated with anticoagulants. Treatment paradigms are shifting from low-molecular-weight heparin monotherapy. Multiple recent randomized controlled trials have demonstrated the safety and efficacy of direct oral anticoagulants in this setting. Current studies are evaluating factor XI inhibitors as potential treatments for cancer-associated VTE.

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来源期刊

Cleveland Clinic Journal of Medicine 医学-医学：内科

CiteScore

3.80

自引率

0.00%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The mission of Cleveland Clinic Journal of Medicine (CCJM) is to provide its readers with up-to-date, practical, clinical information relevant to internal medicine, cardiology, and related fields. Consistent with this mission, CCJM focuses on timely review articles and other content that has a continuing-education orientation rather than on original research or case reports. CCJM authors, drawn from Cleveland Clinic and other top medical institutions throughout the world, are asked to identify new findings that are changing the practice of medicine and to advise readers how to apply them in daily patient care. Authors are chosen for their experience, acquired through caring for patients, teaching other physicians, and researching clinical questions.