脑脊液嗜铬粒蛋白 A 在区分阿尔茨海默病和路易体痴呆症方面的诊断价值

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Neuropathology and Applied Neurobiology Pub Date : 2024-02-01 DOI:10.1111/nan.12961

Olivier Bousiges, Thomas Lavaux, Catherine Demuynck, Caroline Schaeffer-Agalède, Nathalie Philippi, Candice Muller, Benjamin Cretin, Frédéric Blanc

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引用次数: 0

摘要

嗜铬粒蛋白 A（CgA）似乎与阿尔茨海默病（AD）和路易体痴呆（DLB）等不同神经退行性病变的病理生理学有关。CgA 存在于淀粉样蛋白斑块的聚集体和路易体中，但 CgA 还通过小胶质细胞在神经炎症过程中发挥作用。我们的目的是确定 AD 和 DLB 患者脑脊液（CSF）中的 CgA 浓度是否存在差异，以及 CgA 浓度是否能区分这两种疾病。

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Diagnostic value of CSF chromogranin A to discriminate between Alzheimer's disease and dementia with Lewy bodies

Chromogranin A (CgA) seems to be involved in the pathophysiology of different neurodegenerative pathologies such as Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB). CgA is present in the aggregates of amyloid plaques and in Lewy bodies but CgA also has a function in neuroinflammatory processes via microglia. Our objective was to determine if there is a difference in the CgA concentration in the cerebrospinal fluid (CSF) of AD and DLB patients and whether the CgA concentration can discriminate between the two diseases.

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来源期刊

Neuropathology and Applied Neurobiology 医学-病理学

CiteScore

8.20

自引率

2.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Neuropathology and Applied Neurobiology is an international journal for the publication of original papers, both clinical and experimental, on problems and pathological processes in neuropathology and muscle disease. Established in 1974, this reputable and well respected journal is an international journal sponsored by the British Neuropathological Society, one of the world leading societies for Neuropathology, pioneering research and scientific endeavour with a global membership base. Additionally members of the British Neuropathological Society get 50% off the cost of print colour on acceptance of their article.