Payman Bagheri, Majid Nouri, Hesam Eskandarzadeh, Mohammad Darvishi
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引用次数: 0
摘要
背景：众所周知，慢性鼻窦炎是一种常见的炎症性和过敏性鼻炎。慢性鼻炎的发病与多种因素有关，包括免疫球蛋白 E（IgE）的产生和维生素 D 的缺乏：本研究调查了 IgE 和维生素 D 缺乏的作用以及慢性过敏性鼻窦炎患者与对照组之间的差异：在这项横断面相关描述性研究中，共有 90 名受试者被分为 3 组（n=30）。受试者分为三组，包括对照组（健康受试者）、慢性鼻窦炎患者和过敏患者。研究人员使用核对表收集必要的数据，包括年龄、性别和体重指数（BMI）。为了评估血清中维生素 D3 和 IgE 的水平，使用了 ELISA 试剂盒：结果：维生素 D 的平均值为 22 克/毫升。在所有参与者中，54 人（60%）维生素 D 不足，13% 的人维生素 D 缺乏，过敏性鼻窦炎患者维生素 D 缺乏和不足的比例较高。我们的研究结果表明，性别（女性）与维生素 D 缺乏显著相关（P =0.01）。所有研究对象中有 39 人（43.3%）的 IgE 偏高，其中过敏性鼻窦炎组的 IgE 异常水平最高。此外，研究还发现性别与 IgE 的关系并不明显。然而，在过敏性鼻窦炎组中，IgE 与维生素 D 缺乏明显相关：我们的研究结果表明，大多数慢性和过敏性鼻窦炎患者体内维生素 D 不足。这项研究表明，过敏性鼻窦炎患者可能更容易受到血清维生素 D 水平较低的影响。
Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study.
Background: Chronic rhinosinusitis is known as a common problem with inflammatory and allergic causes. Several factors are associated with developing chronic rhinosinusitis, including immunoglobulin E (IgE) production and vitamin D deficiency.
Objective: In this study, we investigated the role of IgE and Vitamin D deficiency and differences between patients with chronic, allergic sinusitis and controls.
Methods: A total of 90 subjects were included in 3 groups (n=30) in this cross-sectional, correlational descriptive study. The subjects were divided into three groups, including control (healthy subjects), chronic sinusitis patients, and allergy patients. A checklist was used to collect the necessary data, including age, gender, and body mass index (BMI). To evaluate serum levels of vitamin D3 and IgE, ELISA kits were used.
Results: The mean vitamin D was 22 g/ml. Fifty-four participants (60%) out of all included people had insufficient vitamin D, 13% had a deficiency, and the high deficiency and insufficiency were in the group of allergic sinusitis. Our results indicated that gender (female) was significantly associated with vitamin D deficiency (p =0.01). Thirty-nine participants (43.3%) out of all studied subjects had high IgE, and the highest level of abnormality of IgE was in the allergic sinusitis group. Furthermore, it was found that gender and IgE were not significantly related. However, IgE was significantly associated with vitamin D deficiency in the allergic sinusitis group.
Conclusion: Our findings highlighted that most of the patients with chronic and allergic sinusitis had insufficient vitamin D. A possible association was also found between low vitamin D and IgE levels and the prevalence of allergic sinusitis. This study showed that patients with allergic sinusitis may be more vulnerable to lower serum levels of vitamin D. Therefore, vitamin D supplementation as an adjunctive therapy may be considered in these patients.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
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