异戊烯基半胱氨酸羧基甲基转移酶(ICMT)可促进癌细胞中侵袭性细胞嵴的形成和转移

IF 3.3 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Carla Borini Etichetti , Evelyn Arel Zalazar , Carolina Di Benedetto , Nabila Cocordano , Sabrina Valente , Silvio Bicciato , Mauricio Menacho-Márquez , María Cecilia Larocca , Javier Girardini
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引用次数: 0

摘要

异戊烯基半胱氨酸羧基甲基转移酶(ICMT)催化了前酰化途径的最后一步。此前,我们发现高水平的 ICMT 会增强体内的肿瘤发生,而且它的表达会受到 p53 肿瘤抑制因子的抑制。有证据表明,一些 ICMT 底物会影响侵袭性状,因此我们想知道这种酶是否会促进转移。在这项工作中,我们发现 ICMT 的过表达增强了体内的肺转移。相应地,ICMT 的过表达也促进了体外与侵袭性表型相关的细胞功能,如迁移和侵袭。考虑到一些 ICMT 底物参与肌动蛋白细胞骨架的调控,我们推测与侵袭和转移相关的富含肌动蛋白的结构可能会受到影响。我们的研究结果表明,ICMT 促进了侵袭性匍匐茎的形成。此外,通过分析癌症患者数据库,我们发现 ICMT 在几种肿瘤类型中都有过表达。此外,ICMT 和 CTTN(编码侵袭灶的重要组成部分)的同时表达与临床预后有显著相关性。总之,我们的工作确定了 ICMT 过表达是人类癌症中的一种相关改变,它促进了转移性肿瘤的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isoprenylcysteine carboxyl methyltransferase (ICMT) promotes invadopodia formation and metastasis in cancer cells

Isoprenyl cysteine carboxyl methyltransferase (ICMT) catalyzes the last step of the prenylation pathway. Previously, we found that high ICMT levels enhance tumorigenesis in vivo and that its expression is repressed by the p53 tumor suppressor. Based on evidence suggesting that some ICMT substrates affect invasive traits, we wondered if this enzyme may promote metastasis. In this work, we found that ICMT overexpression enhanced lung metastasis in vivo. Accordingly, ICMT overexpression also promoted cellular functions associated with aggressive phenotypes such as migration and invasion in vitro. Considering that some ICMT substrates are involved in the regulation of actin cytoskeleton, we hypothesized that actin-rich structures, associated with invasion and metastasis, may be affected. Our findings revealed that ICMT enhanced the formation of invadopodia. Additionally, by analyzing cancer patient databases, we found that ICMT is overexpressed in several tumor types. Furthermore, the concurrent expression of ICMT and CTTN, which encodes a crucial component of invadopodia, showed a significant correlation with clinical outcome. In summary, our work identifies ICMT overexpression as a relevant alteration in human cancer that promotes the development of metastatic tumors.

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来源期刊
Biochimie
Biochimie 生物-生化与分子生物学
CiteScore
7.20
自引率
2.60%
发文量
219
审稿时长
40 days
期刊介绍: Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English. Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.
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