2018-2022年中国武汉COVID-19大流行期间14岁及以下住院儿童呼吸道病毒感染流行病学研究。

IF 1 Q4 INFECTIOUS DISEASES
Journal of Global Infectious Diseases Pub Date : 2023-11-30 eCollection Date: 2023-10-01 DOI:10.4103/jgid.jgid_138_23
Yingchan Hao, Li Cheng, Dan Lu
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引用次数: 0

摘要

导言:初步研究COVID-19大流行期间武汉市急性呼吸道感染住院患儿的病毒病原学特征及流行情况,为更好地了解各种病原体在病例中的作用,预防和临床治疗急性呼吸道感染提供可靠的科学依据:选取2018年1月至2022年12月在我科住院治疗的急性呼吸道感染患儿共69086名作为研究对象。收集患者的社会人口学和临床数据以及鼻咽部样本。通过直接免疫荧光法(DFA)检测呼吸道合胞病毒(RSV)、腺病毒(ADV)、甲型流感病毒(FluA)、乙型流感病毒(FluB)和副流感病毒(PIV),以了解和分析COVID-19大流行期间儿童呼吸道病原体的流行特点:在 69086 名住院儿童中,呼吸道病原体的总检出率为 24.52%。ADV、RSV、FluA、FluB 和 PIV 中呼吸道病毒的检出率分别为 14.67%、46.40%、7.76%、5.23% 和 25.95%。各种病原体之间存在明显差异(P < 0.001)。在 COVID-19 大流行期间,2020 年的病原体阳性患者最少,阳性检出率也最低。不同年份的病原体检出率存在明显差异(P < 0.001)。此外,结果显示,不同年龄组的呼吸道病毒检测总检出率存在显著差异(P < 0.001)。1-3 岁年龄组的阳性检出率最高,因为该年龄组容易发生急性呼吸道感染。我们还发现,不同病原体有明显的季节性波动和流行。RSV 在冬季达到高峰。ADV 主要流行于春季和夏季。FluA 在冬季的检出率较高。结论:2018年至2022年武汉市住院儿童急性呼吸道感染病原体的流行病学分布随性别、年龄和季节而变化。非药物干预(NPIs)作为控制措施在全球范围内实施,减少了呼吸道病原体的传播。NPIs很可能是COVID-19大流行初期呼吸道病毒感染活动急剧减少的主要驱动力,以溶解NPIs会导致病毒感染病原体复发,尤其是在儿童中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiological Study of Respiratory Virus Infections among Hospitalized Children Aged 14 Years and Younger during COVID-19 Pandemic in Wuhan, China, 2018-2022.

Introduction: The viral etiological characteristics and prevalence of hospitalized children with acute respiratory tract infection were preliminary studied in Wuhan City during the COVID-19 pandemic, to provide a reliable scientific basis for better understanding of the role of various pathogens in cases and for the prevention and clinical treatment of acute respiratory tract infection.

Methods: A total of 69,086 children with acute respiratory infections hospitalized and treated in our department from January 2018 to December 2022 were enrolled as our research subjects. Sociodemographic and clinical data as well as nasopharyngeal samples were collected from patients. Respiratory syncytial virus (RSV), adenovirus (ADV), infuenza virus A (FluA), infuenza virus B (FluB), and parainfluenza virus (PIV) were detected by direct immunofluorescence (DFA) to understand and analyze the epidemic characteristics of respiratory pathogens in children during the COVID-19 pandemic.

Results: The total detection rate of respiratory pathogens was 24.52% of the 69,086 hospitalized children. The frequency of respiratory viruses in those ADV, RSV, FluA, FluB, and PIV was 14.67%, 46.40%, 7.76%, 5.23%, and 25.95%. There were significant differences between the various pathogens (P < 0.001). There were the fewest pathogen-positive patients and positive detection rate in 2020 during the COVID-19 pandemic. There were significant differences in the pathogen detection rate among different years (P < 0.001). In addition, the results showed that the total detection rate of respiratory virus tested in different age groups was significantly different (P < 0.001). The positive detection rate was highest in the 1-3-year-old age group, which is prone to acute respiratory infections. We also found that different pathogens showed obvious seasonal fluctuation and epidemic. RSV reached its peak in winter. ADV is mainly prevalent in spring and summer. FluA has a high detection rate in winter. Winter and spring are the peak seasons for FluB infection, whereas PIV is detected in all seasons, with a higher incidence rate in the spring and summer.

Conclusion: The epidemiological distribution of pathogens of acute respiratory tract infection in hospitalized children in Wuhan from 2018 to 2022 varies with gender, age, and season. Nonpharmaceutical interventions (NPIs) were implemented as control measures worldwide and reduced the transmission of respiratory pathogens. NPIs are likely to be the primary driver of the dramatic reduction in respiratory virus infection activity in the early stages of the COVID-19 pandemic, to dissolving NPIs can lead to a recurrence of viral infection pathogens, especially in children.

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来源期刊
CiteScore
3.30
自引率
0.00%
发文量
31
审稿时长
29 weeks
期刊介绍: JGID encourages research, education and dissemination of knowledge in the field of Infectious Diseases across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in Infectious Diseases to promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.
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