Yang Shen, Yuxi Chen, Shufeng Zhang, Ze Wu, Xiaoyu Lu, Weizhen Liu, Bang Liu, Xiang Zhou
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引用次数: 0
摘要
肌内脂肪（IMF）含量和分布对猪肉的食用品质有很大影响。然而，目前用于测量这些性状的方法复杂、耗时且成本高昂。为了简化测量过程，本研究开发了一款名为 "猪肉肌内脂肪 "的智能手机应用程序（App）。该应用程序是一种快速、便携的表型工具，用于获取猪肉图像，并通过嵌入式深度学习算法提取基于图像的 IMF 特征。利用该应用程序，我们收集了大白×桐城猪杂交群体背阔肌的 IMF 性状。全基因组关联研究分别发现了 13 个和 16 个与 IMF 含量和分布显著相关的 SNPs，其中 NR2F2、MCTP2、MTLN、ST3GAL5、NDUFAB1 和 PID1 为候选基因。我们的研究引入了一种用户友好型数字表型技术来量化IMF性状，并为猪IMF性状的遗传改良提出了候选基因和SNPs。
Smartphone-based digital phenotyping for genome-wide association study of intramuscular fat traits in longissimus dorsi muscle of pigs
Intramuscular fat (IMF) content and distribution significantly contribute to the eating quality of pork. However, the current methods used for measuring these traits are complex, time-consuming and costly. To simplify the measurement process, this study developed a smartphone application (App) called Pork IMF. This App serves as a rapid and portable phenotyping tool for acquiring pork images and extracting the image-based IMF traits through embedded deep-learning algorithms. Utilizing this App, we collected the IMF traits of the longissimus dorsi muscle in a crossbred population of Large White × Tongcheng pigs. Genome-wide association studies detected 13 and 16 SNPs that were significantly associated with IMF content and distribution, respectively, highlighting NR2F2, MCTP2, MTLN, ST3GAL5, NDUFAB1 and PID1 as candidate genes. Our research introduces a user-friendly digital phenotyping technology for quantifying IMF traits and suggests candidate genes and SNPs for genetic improvement of IMF traits in pigs.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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