失踪的氢离子,第二部分:证据指向何处

IF 2.3 Q2 SPORT SCIENCES
Robert Robergs , Bridgette O’Malley , Sam Torrens , Jason Siegler
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引用次数: 0

摘要

本手稿旨在提供证据,说明细胞为什么不产生代谢酸。此外,还提供了反对支持细胞产生乳酸(HLa)或肝酮酸的常见观点和论据的证据。有机化学发现,许多参与细胞能量代谢的分子都含有被归类为酸的官能团。这些分子中容易释放 H+的两个主要酸性官能团是羧基和磷酸基结构,尽管具有这些结构的分子的生物化学和有机化学显示它们是以非酸性离子(带负电荷)结构产生的,从而防止了依赖于 pH 值的 H+释放。从 HLa 的工业生产中获得的补充证据进一步表明,乳酸(La-)产生后,由于与 pH 值相关的 ∼H+ 关联,酸化步骤会将 La- 转化为 HLa。有趣的是,还有许多其他分子被归类为酸,与 HLa 相比,它们的 H+解离常数(pKd)值相似。在许多新陈代谢条件下,这些分子的累积周转率远远高于 La-。这些证据证明了细胞产生 HLa 或其他代谢酸的非经验基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The missing hydrogen ion, part-2: Where the evidence leads to

The purpose of this manuscript was to present the evidence for why cells do not produce metabolic acids. In addition, evidence that opposes common viewpoints and arguments used to support the cellular production of lactic acid (HLa) or liver keto-acids have been provided. Organic chemistry reveals that many molecules involved in cellular energy catabolism contain functional groups classified as acids. The two main acidic functional groups of these molecules susceptible to ∼H+ release are the carboxyl and phosphoryl structures, though the biochemistry and organic chemistry of molecules having these structures reveal they are produced in a non-acidic ionic (negatively charged) structure, thereby preventing pH dependent ∼H+ release. Added evidence from the industrial production of HLa further reveals that lactate (La) is produced followed by an acidification step that converts La to HLa due to pH dependent ∼H+ association. Interestingly, there is a plentiful list of other molecules that are classified as acids and compared to HLa have similar values for their H+ dissociation constant (pKd). For many metabolic conditions, the cumulative turnover of these molecules is far higher than for La. The collective evidence documents the non-empirical basis for the construct of the cellular production of HLa, or any other metabolic acid.

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来源期刊
Sports Medicine and Health Science
Sports Medicine and Health Science Health Professions-Physical Therapy, Sports Therapy and Rehabilitation
CiteScore
5.50
自引率
0.00%
发文量
36
审稿时长
55 days
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