Sten-O Starter 对丹麦北部地区 1 型糖尿病儿童和青少年血糖管理的影响

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-24 DOI:10.1016/j.deman.2024.100200

C. Bender , M.H. Jensen , S.B. Skindbjerg , A. Nielsen , C. Feldthaus , S. Hangaard , L.A. Hasselbalch , M. Madsen , O. Hejlesen , S.L. Cichosz

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引用次数: 0

摘要

目标有关 1 型糖尿病（T1D）的教育材料非常有限。一种名为 "Sten-O Starter "的教育应用程序已在 T1D 儿童和青少年及其父母中使用，但其对血糖管理的影响尚不清楚。方法比较两个队列（干预组接受 Sten-O Starter，对照组接受常规护理）在确诊后 0-12 个月的糖化血红蛋白 (HbA1c) 水平。研究采用了重复测量混合模型，并对年龄、性别和确诊时的 HbA1c 进行了调整。结果 181 名儿童和青少年被纳入研究，从诊断到 12 个月随访期间的所有 HbA1c 测量结果显示：各组间的 HbA1c 变化无显著差异（p = 0.35）。然而，干预队列与对照队列在随访 12 个月时的 HbA1c 中位数（50 mmol/mol 对 54 mmol/mol）差异有边缘显著性（p = 0.059）。对 30 名儿童和青少年进行的亚组分析表明，TBR 在 6 个月和 12 个月时有显著差异（干预组：1.2% vs 对照组：2.6%；p = 0.02）（干预组：1% vs 对照组；2%；p = 0.05）。

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Impact of Sten-O Starter on Glycemic Management in Children and Adolescents with Type 1 Diabetes in the North Region of Denmark

Objective

Educational material on type 1 diabetes (T1D) is limited. An educational application named Sten-O Starter has been implemented for children and adolescents with T1D and their parents; however, its effect on glycemic management is unknown. The objective was therefore to examine the clinical impact of the Sten-O Starter on glycemic management among children and adolescents with T1D.

Methods

The levels of glycated hemoglobin (HbA1c) at 0–12 months after diagnosis were compared between two cohorts (the intervention received Sten-O Starter and the control received usual care). A mixed model of repeated measurements adjusted for age, sex, and HbA1c at diagnosis was used. A subgroup analysis of the cohorts was performed in which the time in range, time above range, and time below range (TBR) were compared at 6 months and 12 months after diagnosis using the Wilcoxon rank sum test.

Results

181 children and adolescents were included and all HbA1c measurements from the time of diagnosis to 12-month follow-up: No significant difference (p = 0.35) was found in HbA1c changes between the cohorts. However, the difference in median HbA1c at the 12-month follow-up between the intervention cohort and the control cohort (50 mmol/mol vs. 54 mmol/mol) was borderline significant (p = 0.059). A subgroup analysis of 30 children and adolescents revealed that TBR was significantly different (intervention: 1.2 % vs control: 2.6 %; p = 0.02) at 6 months and at 12 months (intervention: 1 % vs control; 2 %; p = 0.05).

Conclusion

The results indicate improved glycemic management among children and adolescents with T1D after use of the Sten-O Starter.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.