核形状和力学的生物物理决定因素及其对基因组完整性的影响

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
S. Hervé, Y.A. Miroshnikova
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引用次数: 0

摘要

核包膜(NE)具有双重作用,既是基因组的保护壳,也是将细胞划分为胞质和核域的重要交流界面。核膜由核片层蛋白、异染色质、核孔和其他在调节基因组三维结构中起关键作用的核膜蛋白组成的综合支架加固。重要的是,这个界面处于力传导的直接路径上,它来自细胞外环境,由细胞自身产生,导致细胞核变形。NE成分机械特性的改变对细胞功能障碍、衰老和疾病有着深远的影响。在此,我们将讨论有关核外围生物物理特性的一些最新发现,以及NE衍生信号和核重塑如何作为基因组完整性、正常倍性和细胞功能的看门人。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Biophysical determinants of nuclear shape and mechanics and their implications for genome integrity

Biophysical determinants of nuclear shape and mechanics and their implications for genome integrity

The nuclear envelope (NE) has a dual role of serving as a protective shell for the genome and a critical communication interface that compartmentalizes cells into cytoplasmic and nuclear domains. The NE is reinforced by the integrated scaffold of nuclear lamins, heterochromatin, nuclear pores, and other NE proteins with critical roles in regulating the three-dimensional architecture of the genome. Importantly, this interface is in the direct path of force transduction, emanating from the cell-extrinsic environment and generated by the cells themselves, leading to deformation of the nucleus. Alterations in the mechanical properties of NE components have profound implications for cellular dysfunction, aging, and disease. Here we discuss some of the recent findings on the biophysical properties of the nuclear periphery and how NE-derived signaling and nuclear remodeling serve as gatekeepers of genome integrity, normal ploidy, and cellular function.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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