{"title":"靶向表观遗传修饰因子:癌症治疗及其他领域的前景广阔的战略","authors":"D. Chanchal, Prateek Porwal, Nidhi Mittal","doi":"10.2174/0115748855275769231114094037","DOIUrl":null,"url":null,"abstract":"\n\nEpigenetic changes are important for controlling how genes are expressed and how cells\nwork, and their misregulation has been linked to many diseases, including cancer. Targeting epigenetic\nmodifiers has become a promising way to treat cancer, and it may also be useful outside of\noncology. This review article goes into detail about the rapidly changing field of epigenetic-based\ntherapies, with a focus on how they are used to treat cancer. We discuss in-depth the main epigenetic\nchanges seen in cancer, such as DNA methylation, changes to histones, and dysregulation of noncoding\nRNA, as well as their roles in tumour growth, metastasis, and drug resistance. Epigenetic\ndrugs and small molecule inhibitors that target epigenetic enzymes and reader proteins have shown a\nlot of promise in both preclinical and clinical studies on different types of cancer. We show the most\nrecent evidence that these epigenetic therapies work and look into how they might be used in combination\nwith other treatments. We talk about new research into the therapeutic potential of epigenetic\nmodifiers in diseases other than cancer, such as neurological disorders, autoimmune diseases, and\nheart conditions. Even though there is a lot of potential for therapy, there are still problems, such as\nside effects and differences between patients. We talk about the work that is still being done to get\naround these problems and explain new ways to deliver epigenetic-based interventions that are more\nprecise and effective. For epigenetic-based therapies to be used in clinical settings, it is important to\nunderstand how they work and how they interact with other types of treatment. As the field moves\nforward, we try to figure out where it is going and what it means to target epigenetic modifiers in\ncancer therapy and other areas of disease. This review looks at the role of epigenetic modulation in\nshaping the landscape of precision medicine and its possible effects on human health from a broad\nand forward-looking point of view.\n","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeting Epigenetic Modifiers: Promising Strategies for Cancer Therapy\\nand Beyond\",\"authors\":\"D. 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引用次数: 0
摘要
表观遗传变化对于控制基因的表达方式和细胞的工作方式非常重要,它们的失调与包括癌症在内的许多疾病有关。靶向表观遗传修饰因子已成为治疗癌症的一种很有前景的方法,而且在肿瘤学之外也可能有用。这篇综述文章详细介绍了瞬息万变的表观遗传疗法领域,重点是如何利用这些疗法治疗癌症。我们深入讨论了癌症中出现的主要表观遗传变化,如 DNA 甲基化、组蛋白变化和非编码核糖核酸调控失调,以及它们在肿瘤生长、转移和耐药性中的作用。针对表观遗传酶和读取蛋白的表观遗传药物和小分子抑制剂在不同类型癌症的临床前和临床研究中都显示出了广阔的前景。我们将展示这些表观遗传疗法有效的最新证据,并探讨如何将它们与其他疗法结合使用。我们还讨论了表观遗传修饰剂在癌症以外的其他疾病(如神经系统疾病、自身免疫性疾病和心脏病)中的治疗潜力的新研究。尽管治疗潜力巨大,但仍存在一些问题,如副作用和患者之间的差异。我们将讨论为解决这些问题仍在进行的工作,并解释提供更精确、更有效的表观遗传干预的新方法。要想在临床环境中使用基于表观遗传的疗法,就必须了解这些疗法是如何起作用的,以及它们与其他类型的治疗是如何相互作用的。随着这一领域的发展,我们试图弄清其发展方向,以及针对癌症治疗和其他疾病领域的表观遗传修饰物意味着什么。这篇综述从广阔而前瞻性的视角审视了表观遗传修饰在塑造精准医疗格局中的作用及其对人类健康可能产生的影响。
Targeting Epigenetic Modifiers: Promising Strategies for Cancer Therapy
and Beyond
Epigenetic changes are important for controlling how genes are expressed and how cells
work, and their misregulation has been linked to many diseases, including cancer. Targeting epigenetic
modifiers has become a promising way to treat cancer, and it may also be useful outside of
oncology. This review article goes into detail about the rapidly changing field of epigenetic-based
therapies, with a focus on how they are used to treat cancer. We discuss in-depth the main epigenetic
changes seen in cancer, such as DNA methylation, changes to histones, and dysregulation of noncoding
RNA, as well as their roles in tumour growth, metastasis, and drug resistance. Epigenetic
drugs and small molecule inhibitors that target epigenetic enzymes and reader proteins have shown a
lot of promise in both preclinical and clinical studies on different types of cancer. We show the most
recent evidence that these epigenetic therapies work and look into how they might be used in combination
with other treatments. We talk about new research into the therapeutic potential of epigenetic
modifiers in diseases other than cancer, such as neurological disorders, autoimmune diseases, and
heart conditions. Even though there is a lot of potential for therapy, there are still problems, such as
side effects and differences between patients. We talk about the work that is still being done to get
around these problems and explain new ways to deliver epigenetic-based interventions that are more
precise and effective. For epigenetic-based therapies to be used in clinical settings, it is important to
understand how they work and how they interact with other types of treatment. As the field moves
forward, we try to figure out where it is going and what it means to target epigenetic modifiers in
cancer therapy and other areas of disease. This review looks at the role of epigenetic modulation in
shaping the landscape of precision medicine and its possible effects on human health from a broad
and forward-looking point of view.
期刊介绍:
Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.